Cocaine and Opiates Use in Pregnancy: Detection of Drugs in Neonatal Meconium and Urine

Institute of Legal Medicine, Forensic Toxicology Service, Faculty of Medicine, University of Santiago de Compostela, San Francisco, s/n, 15782, Santiago de Compostela, Spain.
Journal of analytical toxicology (Impact Factor: 2.86). 09/2009; 33(7):351-5. DOI: 10.1093/jat/33.7.351
Source: PubMed


In this study, the case of a newborn with symptoms of hyperexcitability was analyzed. After it was confirmed in the hospital that the mother had consumed drugs during pregnancy using an enzyme multiplied immunoassay technique, samples of the newborn's urine and meconium were sent to our laboratory to observe the evolution in the distribution of cocaine and opiates during the days following birth. For urine analysis, screening was done with an immunoassay technique, and the confirmation was done by gas chromatography-mass spectrometry (GC-MS) according to a published method. A GC-MS method for simultaneous analysis of cocaine, benzoylecgonine, codeine, morphine, and 6-acetylmorphine in meconium is described. GC-MS confirmation of urine and meconium results showed consumption of cocaine and codeine during pregnancy and also showed the levels of drugs gradually declined, totally disappearing by the third day.

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    • "COC and its metabolites have been detected in different maternal fetus and neonatal matrices including urine, blood, hair samples, neonatal gastric fluid, neonatal nails, meconium, amniotic fluid and umbilical cord blood [9] [10]. Urine and meconium are the preferred specimens for analysis, but the detection of COC and metabolites in such samples does not explain the distribution of COC [11] [12]. "
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