Prevention of striae gravidarum with cocoa butter cream
ABSTRACT To determine whether cocoa butter cream is effective in preventing striae gravidarum.
This randomized, double-blind, placebo-controlled trial enrolled 300 pregnant women: 150 women received cocoa butter cream and 150 women received a placebo cream. The women were followed-up from 16 weeks of pregnancy to delivery to assess the development of striae gravidarum. Maternal height, weight, and abdominal girth were recorded at each visit. After delivery the placenta was weighed, and anthropometry and Apgar scores of the neonate were recorded.
The 2 groups had similar clinical parameters at booking. Striae gravidarum developed in 44% of patients using cocoa butter cream compared with 55% of those using placebo; the difference was not significant (chi(2)=2.8, df(1), P=0.09). Striae gravidarum were more common among younger women and those with large neonates. However, no relationship was found between development of striae and body mass index.
Cocoa butter cream does not prevent striae gravidarum. In Afro-Caribbean women, development of striae is related to young age of the mother and large neonates.
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ABSTRACT: Striae gravidarum (SG), or stretch marks developing during pregnancy, affect up to 90% of women. While not medically dangerous, SG can be disfiguring, causing emotional and psychological distress. However, studies specifically addressing the prevention of SG, especially during pregnancy, are sparse. Furthermore, the molecular pathogenesis of SG is unclear and may differ from that of striae from other causes. Considering these factors, we review topical modalities that have been used specifically for preventing SG during pregnancy. We identify two major strategies (endpoints) for these modalities, including 1) preventing the de novo development of SG, and 2) reducing the severity of SG that have recently developed. We also identify risk factors for the development of SG and suggest that pregnant women with these risk factors are an appropriate target population for prevention. In reviewing the literature, we find that there is limited evidence that centella and possibly massage with bitter almond oil may prevent SG and/or reduce their severity. There is weak evidence that hyaluronic acid prevents SG. Tretinoin holds promise for reducing the severity of new-onset SG, but its use is limited by its pregnancy category. Finally, cocoa butter and olive oil are not effective for preventing SG or reducing the severity of lesions. We conclude that reliable methods for preventing SG are scarce. Furthermore, available topical modalities generally lack strong evidence from rigorous, well-designed, randomized controlled trials with ample numbers of subjects. Thus, further research is necessary to better elucidate SG pathogenesis, which may lead to effective prevention modalities.This article is protected by copyright. All rights reserved.British Journal of Dermatology 09/2014; 172(3). DOI:10.1111/bjd.13426 · 4.10 Impact Factor
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ABSTRACT: BACKGROUND: Striae gravidarum is a physiological skin change that many pregnant women experience during pregnancy. The striae are often accompanied by a reddish purple color during pregnancy, and then lose pigmentation and become atrophic in the long term after pregnancy. Striae gravidarum seems to be undesirable to many pregnant women. However, the impact of striae gravidarum on pregnant women who experience it has not been clarified. The aim of this study was to evaluate the impact of striae gravidarum on the generic and dermatology-specific quality of life (QOL) of pregnant women. METHODS: A cross-sectional study was conducted at three private clinics in a typical urban area in Japan. We recruited 447 pregnant women at 36 weeks of gestation; One hundred and ninety-nine pregnant women at 36 weeks of gestation participated in the study and 179, consisting of 94 primiparae and 85 multiparae, were analyzed.We used and assessed Davey's score for striae gravidarum, World Health Organization Quality of Life assessment questionnaire for generic QOL, and Skindex-29 for dermatology-specific QOL. RESULTS: The prevalence of striae gravidarum was 39.1% (27.7% in primiparae, and 51.8% in multiparae). Although there were no differences in generic QOL scores between the presence and absence of striae gravidarum and with their severity, the whole group of pregnant women and the multiparae group showed significant differences in scores on emotion of Skindex-29 between the presence and absence of striae gravidarum (p = 0.012 and p = 0.011). Pregnant women with severe striae gravidarum showed significantly higher scores on emotion of Skindex-29 compared with those with absent or mild striae gravidarum (p < 0.001 and p = 0.005). CONCLUSIONS: There was no difference in generic QOL of pregnant women between the presence and absence of striae gravidarum, although the occurrence and severity of striae gravidarum influenced their dermatology-specific QOL. Multiparae women were especially impaired by striae gravidarum and it is considered important to prevent or reduce the severity of striae gravidarum of the multiparae group.BMC Research Notes 08/2012; 5(1):450. DOI:10.1186/1756-0500-5-450
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ABSTRACT: Striae gravidarum (SG) is one of the cutaneous physiological changes during pregnancy with a high prevalence. This study aimed to evaluate the effect of olive oil in prevention of SG. Randomized controlled clinical trial. Health care centers and three Hospitals affiliated to Tehran University of Medical Sciences. 100 nulliparous pregnant women. Fifty women were randomly allocated to each study group. The treatment group received 1 cc topical olive oil twice a day to apply on the abdominal skin in a gentle manner without massaging it until the delivery. Control group did not receive any cream or oil during the study. Development of SG and its severity was recorded at the end of the study. Although the frequency of severe SG was lower in the users of olive oil compared to the other group, no statistically significant difference was found between the two experimental groups and the control group in the incidence and the severity of SG. Olive oil reduces the incidence of severe SG and increases the incidence of mild SG, but it does not significantly reduce the incidence and the severity of SG and it could not be recommended for SG prevention.Complementary therapies in medicine 10/2012; 20(5):263-6. DOI:10.1016/j.ctim.2012.05.001 · 2.22 Impact Factor