Hantavirus infection in the Republic of Georgia.

Technology Management Company, Tbilisi, Georgia.
Emerging Infectious Diseases (Impact Factor: 7.33). 09/2009; 15(9):1489-91. DOI: 10.3201/eid1509.090617
Source: PubMed

ABSTRACT We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia. Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia. Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen.

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    ABSTRACT: Minimal information is available on the incidence of Crimean-Congo hemorrhagic fever (CCHF) virus and hantavirus infection in Georgia. From 2008 to 2011, 537 patients with fever ≥38°C for ≥48 hours without a diagnosis were enrolled into a sentinel surveillance study to investigate the incidence of nine pathogens, including CCHF virus and hantavirus. Positive enzyme-linked immunosorbent assay (ELISA) results were confirmed by immunoglobulin M (IgM)/IgG immunofluorescent assay (IFA) and IgM/IgG immunoblotting for hantavirus. Three of fourteen patients with hemorrhagic fever syndrome tested positive for CCHF virus IgM antibodies. Two patients with fever of unknown origin (FUO) and acute renal failure tested positive for acute hantavirus infection. It is important to make the Georgian medical community aware of the characteristics of viral hemorrhagic fever infections in Georgia. Additional studies of CCHF virus and hantavirus strains as well as sentinel laboratory surveillance are needed to improve diagnosis, treatment, and control in Georgia.
    The American journal of tropical medicine and hygiene 06/2014; 91(2). DOI:10.4269/ajtmh.13-0460 · 2.74 Impact Factor
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    ABSTRACT: Hantaviruses as a member of the family Bunyaviridae are RNA viruses with enveloped, negative-sense, single-stranded segmental genome. Today, more than 20 different Hantavirus species are recognized. Eleven of them cause clinical symptoms in humans. Hantaan (HTNV), Puumala (PUUV), Dobrava (DOBV), Seoul viruses causes different forms of hemorrhagic fever with renal syndrome (HFRS), since Sin Nombre virus and Sin Nombre-like viruses found especially in the United States causes hantaviruses pulmonary syndrome (HPS) with high mortality. In our country, infections have been reported with subtypes of the Hantaviruses firstly PUUV in the Western Black Sea region, then DOBV from Giresun and Kastamonu. A case of Hantavirus infection similarly in the form of RSHF from the rural area of Kazan district in Ankara has been reported in this article. Sixty-seven-year-old male patient was admitted to the emergency room with complaints of dizziness, fever and fatigue in June of 2011. Leukopenia, thrombocytopenia elevated liver enzymes and creatinine was detected in laboratory investigations at emergency room. The patient hospitalized and followed with initial diagnosis of Crimean-Congo Hemorrhagic Fever (CCHF). Further investigation of the serum samples at the Refik Saydam Hygiene Center and Research Laboratory of Virology with indirect immunofluorescent antibody (IFA) ((Hantaviruses Mosaic-1, Euroimmun, Germany) resulted in weakly positivity of anti-hantavirus IgM and IgG. The first serum samples revealed negative by immunoblot test (Euroimmun, Germany). After 11 days second sample of patient revealed DOBV positivite with both IFA and immunoblot serologically. In-house RT - Polimerase Chain Reaction (PCR) test was found to be negative in the first serum sample of the patient. This case is important of being the first HFRS infection reported from Ankara.
    Türk hijiyen ve deneysel biyoloji dergisi. Turkish bulletin of hygiene and experimental biology 01/2013; 70(1):27-32. DOI:10.5505/TurkHijyen.2013.50103
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    ABSTRACT: Abstract Hantaviruses comprise an emerging global threat for public health, affecting about 30 000 humans annually. Infection may lead to Hantavirus pulmonary syndrome (HPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in the Europe and Asia. Humans are spillover hosts, acquiring infection primarily through the inhalation of aerosolized excreta from infected rodents and insectivores. Risk factors for infection include involvement in outdoor activities, such as rural- and forest-related activities, peridomestic rodent presence, exposure to potentially infected dust and outdoor military training; prolonged, intimate contact with infected individuals promotes transmission of Andes virus, the only Hantavirus known to be transmitted from human-to-human. The total number of Hantavirus case reports is generally on the rise, as is the number of affected countries. Knowledge of the geographical distribution, regional incidence and associated risk factors of the disease are crucial for clinicians to suspect and diagnose infected individuals early on. Climatic, ecological and environmental changes are related to fluctuations in rodent populations, and subsequently to human epidemics. Thus, prevention may be enhanced by host-reservoir control and human exposure prophylaxis interventions, which likely have led to a dramatic reduction of human cases in China over the past decades; vaccination may also play a role in the future.
    Critical Reviews in Microbiology 04/2013; DOI:10.3109/1040841X.2013.783555 · 6.09 Impact Factor

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