Article

Contrast-enhanced myocardial T1-weighted scout (Look-Locker) imaging for the detection of myocardial damages in hypertrophic cardiomyopathy.

Department of Radiology, Nippon Medical School, Tokyo, Japan.
Journal of Magnetic Resonance Imaging (impact factor: 2.7). 10/2009; 30(4):778-84. DOI:10.1002/jmri.21921 pp.778-84
Source: PubMed

ABSTRACT To assess the myocardial damage in hypertrophic cardiomyopathy (HCM) using contrast-enhanced myocardial T1-weighted scout (Look-Locker) magnetic resonance imaging (MRI).
Twenty-three patients with HCM and seven comparative patients without known HCM serving as controls underwent cine, contrast-enhanced myocardial T1-weighted scout and delayed-enhancement MRI using a 1.5T unit. Intervals of null points between myocardium and blood were compared among hyperenhancing and nullified myocardium of HCM and the normal myocardium. The relationship between these myocardial patterns and global cardiac functions was analyzed in HCM.
The hyperenhancing myocardium, dense myocardial fibrosis in HCM had null points significantly shorter than blood, normal myocardium, and nullified myocardium of HCM (P < 0.0001). The number of hyperenhancing myocardial segments correlated with the ejection fraction (P = 0.045). The nullified myocardium of HCM showed shorter intervals of the null points between myocardium and blood than did the normal myocardium, indicating the dispersed myocardial fibrosis (P = 0.0032). The interval of null points between the nullified myocardium and blood showed a significant correlation with the increase in myocardial mass in HCM (P = 0.034).
Contrast-enhanced myocardial T1-weighted scout imaging has the potential for showing dispersed myocardial damage leading to increased myocardial mass in HCM, while the dense myocardial fibrosis correlated with reduced ejection fraction.

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Keywords

comparative patients
 
contrast-enhanced myocardial T1-weighted scout
 
Contrast-enhanced myocardial T1-weighted scout imaging
 
delayed-enhancement MRI
 
dense myocardial fibrosis
 
dense myocardial fibrosis correlated
 
dispersed myocardial fibrosis
 
ejection fraction
 
global cardiac functions
 
HCM
 
hyperenhancing myocardial segments correlated
 
hypertrophic cardiomyopathy
 
myocardial damage
 
myocardial mass
 
myocardial patterns
 
normal myocardium
 
null points
 
nullified myocardium
 
shorter intervals
 
significant correlation
 

Yasuo Amano