Article

The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population.

Toxicogenomics Unit, National Institute of Public Health, Prague 10, 100 42, Czech Republic.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (impact factor: 2.85). 09/2009; 680(1-2):78-81. DOI:10.1016/j.mrgentox.2009.09.005 pp.78-81
Source: PubMed

ABSTRACT In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer.

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Keywords

Czech Republic
 
elevated risk
 
first case-control study
 
GSTP1-codon 105 Val variant allele
 
GSTP1-codon 105 Val variants
 
GSTT1-null
 
GSTT1-null genotype
 
key biotransformation genes
 
pancreatic cancer
 
population-specific associations