Case of pigmented neurofibroma with hypertrichosis with no association to neurofibromatosis

Department of Dermatology, Chosun University, Gwangju, Korea.
The Journal of Dermatology (Impact Factor: 2.25). 10/2009; 36(10):541-4. DOI: 10.1111/j.1346-8138.2009.00698.x
Source: PubMed


Pigmented neurofibroma (PNF) is a rare cutaneous tumor that has been observed in patients with or without neurofibromatosis (NF). This tumor is histologically characterized by the coexistence of scattered melanin-laden cells and benign spindle cells with neural differentiations. Hypertrichosis is the excessive growth of hair on non-androgen-dependent areas of the body. It has been reported that hypertrichosis may sometimes overlie a neurofibroma. We highlight a case of PNF with hypertrichosis on a 17-year-old woman with no associated NF. We also discuss the possible underlying pathogenic mechanism of a localized hypertrichosis in PNF patients.

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