Article

Chemical synthesis in microreactors.

Department of Chemistry, University of Hull, Hull, UK.
Methods in molecular biology (Clifton, N.J.) (Impact Factor: 1.29). 01/2010; 583:109-20. DOI: 10.1007/978-1-60327-106-6_4
Source: PubMed

ABSTRACT To develop a new generation of drugs, pharmaceutical companies need to be able to synthesise and screen novel chemicals with enhanced speed. New technology that would enable a cost neutral step change in the number of potential drug candidates would provide a distinct competitive advantage. Indeed the miniaturisation of chemical reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry, who are constantly searching for controllable, information-rich, high-throughput, environmentally friendly methods of producing products with a high degree of chemical selectivity. This chapter reviews the current and future applications of microreactors that could enhance the drug discovery process.

0 Followers
 · 
160 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This paper presents a method of imaging temperature distributions of sub-millimeter-thick water using a near-infrared camera and optical narrow-bandpass filter. The principle is based on the temperature dependence of the ν1 + ν3 absorption band of water. Temperature images are constructed by measuring the absorbance of water at the wavelength of 1412 nm through the filter for all pixels of the camera. From calibration measurements on 0.5-mm thick water at temperatures from 26.0 °C to 40.0 °C, the temperature coefficient was 6.3 × 10−4 K−1 and the standard deviation of absorbance was 1.9 × 10−4. Thermal diffusion in 0.5-mm thick water caused by a thin heating wire was visualized with this method. The obtained images were verified against temperature distributions calculated by solving a two-dimensional thermal conduction model. This method would be useful for temperature measurement applications and control of aqueous solutions in microchips.
    International Journal of Heat and Mass Transfer 09/2009; 52:4221-4228. DOI:10.1016/j.ijheatmasstransfer.2009.04.024 · 2.52 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 06/2010; 41(24). DOI:10.1002/chin.201024274
  • [Show abstract] [Hide abstract]
    ABSTRACT: The influence of the channel radius on the mass transfer in rectangular meandering microchannels (width and height of ) has been investigated for gas–liquid flow. Laser induced velocimetry measurements have been compared with theoretical results. The symmetrical velocity profile, known from the straight channel, was found to change to an asymmetrical one for the meandering channel configuration. The changes in the secondary velocity profile lead to an enhanced radial mass transfer inside the liquid slug, resulting in a reduced mixing length. In the investigated experimental range (superficial gas velocity and superficial liquid velocity ) the mixing time was reduced eightfold solely due to changes in channel geometry. An experimental study on the liquid slug lengths, the pressure drop and their relation to the mass transfer have also been performed. Experimental results were validated by a simulation done in Comsol Multiphysics®. To obtain information for higher velocity rates, simulations were performed up to . These velocity variations in the simulation indicate the occurrence of a different flow pattern for high velocities, leading to further mass transfer intensification.
    Chemical Engineering Science 03/2009; DOI:10.1016/j.ces.2008.11.019 · 2.61 Impact Factor

Preview

Download
2 Downloads
Available from