Protein networks and pathway analysis. Preface

Methods in Molecular Biology (Impact Factor: 1.29). 01/2009; 563:v-vii. DOI: 10.1007/978-1-60761-175-2
Source: PubMed
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    • "For instance, in pathway analysis (Khatri et al., 2012) and gene set enrichment analysis (Subramanian et al., 2005), multiple genes that work together to serve a particular biological function are often analyzed jointly as a gene set. Several pathway repositories, such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) (Kanehisa et al., 2004), PANTHER classification system for protein sequence data (Nikolsky and Bryant, 2009), and Reactome pathways in humans (Matthews et al., 2009) have been established, and are continually being updated. For non-Mendelian diseases and complex traits, identification of isolated genetic variants is insufficient to summarize the complex association with disease. "
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