Clinical and Resistance Consequences of Misquantification of Plasma and Cerebrospinal Fluid Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Samples from an HIV-1 Subtype G-Infected Patient

Department of Virology, Saint-Louis Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France.
Journal of clinical microbiology (Impact Factor: 3.99). 09/2009; 47(11):3763-4. DOI: 10.1128/JCM.00206-09
Source: PubMed


Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We
report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected
woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.

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Available from: Thomas Mourez, Jun 16, 2014
    • "As this subtype represents only 11% of all circulating strains worldwide [1], and as it has been largely shown that the wide diversity of HIV-1 could lead to major quantification discrepancies [2] [3] [4] [5], it is relevant to evaluate each new version of a quantification assay. Indeed, pVL under-quantification has major clinical repercussions and delays the detection of drug resistance, as we have shown in our previous research [6]. Moreover, these discrepancies are even more pronounced with the highly divergent non-M (N, O, and P) groups of HIV-1 [7] [8]. "
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