Control of bovine fasciolosis in dairy cattle in Switzerland with emphasis on pasture management.
ABSTRACT Thirty-two dairy cattle farms with fasciolosis as an established herd problem were visited and divided into groups according to the location of the habitats of the intermediate host of Fasciola hepatica. The farms were revisited 4-5 years later and those that had followed the recommended measures were compared to those that had not. Egg shedding and seroprevalence was significantly reduced in cows on farms complying with the control recommendations but was not reduced on farms that had not complied.
- Parasitology Research 02/1991; 77(4):364-6. · 2.85 Impact Factor
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ABSTRACT: Triclabendazole (TCBZ) has been the drug of choice to treat liver fluke infections in livestock for >20 years, due to its high activity against both adult and juvenile flukes. More recently, it has been used successfully to treat human cases of fascioliasis. Resistance to TCBZ first appeared in the field in Australia in the mid-1990s. Since then, resistance has been reported from a number of countries throughout Europe: Ireland, Scotland, Wales, Spain and The Netherlands. The heavy reliance on a single drug puts treatment strategies for fascioliasis at risk. Should resistance develop further, the prospect is an alarming one. This review will present an overview of progress in understanding the mechanism of resistance to TCBZ, examining possible changes in the target molecule, in drug influx/efflux mechanisms and in the metabolism of TCBZ by the fluke. The review will also consider ways to deal with resistance, covering drug-oriented options such as: the use of alternative drugs, drug combinations and the search for new compounds.Experimental and Molecular Pathology 04/2007; 82(2):104-9. · 2.13 Impact Factor
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ABSTRACT: A survey of 1,331 cattle presented for slaughter at two abattoirs in Switzerland was used to estimate the true prevalence of Fasciola hepatica infection and the diagnostic parameters of visual meat inspection, coproscopy after sedimentation technique, a commercial ELISA test for specific antibody detection in serum and the post mortem microscopic detection of eggs in bile. Faeces, blood and the gall bladder were taken from most cattle presented for slaughter. In addition, livers that were rejected by the meat inspectors were also dissected to examine for the presence of liver fluke. Bayesian techniques (Markov Chain-Monte Carlo) were used to estimate the diagnostic parameters of each of these procedures and the true prevalence of bovine fasciolosis. The true prevalence of F. hepatica infection was estimated at 18.0% (95% credible intervals 15.9-20.3%). The diagnostic sensitivity of coproscopy, bile examination, antibody ELISA and meat inspection were estimated at 69.0% (57.3-79.7%), 93.4% (88.0-97.5%), 91.7% (87.2-95.2%) and 63.2% (55.6-70.6%), respectively. The diagnostic specificity of the ELISA test was estimated at 93.7% (91.7-95.2%). These results demonstrate that the prevalence of bovine fasciolosis is higher than previously thought due to the low sensitivity of meat inspection. They also demonstrate that traditional coproscopy can be very efficient if there is repeated sampling, resulting in sensitivity of approximately 92%.International Journal for Parasitology 10/2006; 36(10-11):1153-8. · 3.64 Impact Factor