Article

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides.

The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Journal of Natural Products (Impact Factor: 3.29). 09/2009; 72(10):1895-8. DOI: 10.1021/np900397f
Source: PubMed

ABSTRACT Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.

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