Article

The results of adjuvant radiotherapy in endometrial carcinoma.

Department of Radiation Oncology, School of Medicine, Akdeniz University, Antalya, Turkey.
Gynecological Endocrinology (Impact Factor: 1.3). 09/2009; 26(4):240-5. DOI: 10.1080/09513590903225341
Source: PubMed

ABSTRACT To examine the clinical characteristics and treatment outcomes in patients with endometrial cancer receiving adjuvant radiotherapy.
A total of 157 patients who received postoperative radiotherapy (RT) between 1999 and 2008 were evaluated, retrospectively. The mean age was 59 years (34-82). All patients received RT following surgery. Stage distribution was as follows: 92 patients (59%) stage I, 21 patients (13%) stage II, and 44 patients (28%) stage III.
Overall survival rate was 95% at 2 years and 84% at 5 years. By the end of follow up, 135 patients (86%) were disease-free, and 4 (2%) were alive with disease. Univariate and multivariate analyses identified stage, grade, and serosal involvement as significant predictors for overall survival.
The results of our study suggests that early stage, low-grade endometrial cancer with no serosal involvement is associated with a better survival and adjuvant radiotherapy is a well tolerated and effective therapeutic option.

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