Oxygen-ozone therapy in medicine: an update.
ABSTRACT Oxygen-ozone therapy, initially started as an empirical approach, has now reached a stage where most of the biological mechanisms of action of ozone have been clarified, showing that they are in the realm of orthodox biochemistry, physiology and pharmacology. Here we have reviewed a few relevant clinical applications and have shown that ozone therapy is particularly useful in cardiovascular disorders and tissue ischemia. In chronic viral infections, it is unable to eliminate the viremia but it may display supportive help by stimulating the immune system. Recently, its use has been successfully extended to the herniated disk pathology and therapy of primary caries in children.
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ABSTRACT: Ozone has been successfully used in many fields of dentistry so far. Specifically in operative dentistry, it seems that can prevent the beginning and evolving of dental caries due to its proven antibactericidal properties. Although there is lack of organized data in in vitro and in vivo research activities, the use of such an operational device in a dental office could ideally contribute to the general philosophy of minimally invasive dental procedures. In dentistry the current way of using ozon is totally safe and technologically pioneer. The bigger acceptance of the device should be among phobic and young patients. But although promising in the beginning, the device does not have an extensive use in the everyday clinical practice. Despite this fact, the technological knowledge and the effectiveness of such a device have scientific interest. The purpose of this study is the description of all relevant information from in vivo and in vitro studies, concerning ozones use in operative dentistry and the evaluation of its effectiveness towards the treatment of dental caries.Hellenic Stomatological Cronicles. 01/2011;
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ABSTRACT: The aim of this paper is to analyze why ozone can be medically useful when it dissolves in blood or in other biological fluids. In reviewing a number of clinical studies performed in Peripheral Arterial Diseases (PAD) during the last decades, it has been possible to confirm the long-held view that the inverted U-shaped curve, typical of the hormesis concept, is suitable to represent the therapeutic activity exerted by the so-called ozonated autohemotherapy. The quantitative and qualitative aspects of human blood ozonation have been also critically reviewed in regard to the biological, therapeutic and safety of ozone. It is hoped that this gas, although toxic for the pulmonary system during prolonged inhalation, will be soon recognized as a useful agent in oxidative-stress related diseases, joining other medical gases recently thought to be of therapeutic importance. Finally, the elucidation of the mechanisms of action of ozone as well as the obtained results in PAD may encourage clinical scientists to evaluate ozone therapy in vascular diseases in comparison to the current therapies.Journal of Translational Medicine 05/2011; 9:66. · 3.41 Impact Factor
Article: Ozone Therapy as Add-On Treatment in Fibromyalgia Management by Rectal Insufflation: An Open-Label Pilot Study.[show abstract] [hide abstract]
ABSTRACT: Abstract Objectives: The objectives of this study were to evaluate the effectiveness and tolerability of ozone therapy by rectal insufflation as add-on therapy in fibromyalgia management. Design: Patients with fibromyalgia received 24 sessions of ozone therapy during a 12-week period. At each session, the administered dose of ozone was 8 mg (200 mL of gas, at a concentration of 40 μg/mL). Ozone sessions were given 5 days a week during the first 2 weeks, twice a week from weeks 3-6, and weekly from weeks 7-12. Fibromyalgia Impact Questionnaire (FIQ) was the main outcome measure, and was administered at baseline and at weeks 4, 8, and 12. Secondary outcome measures, administered at baseline and at endpoint, were the Pittsburgh Sleep Quality Index, the Beck Depression Inventory, the State and Trait Anxiety Inventory, and the SF-12, the abbreviated form of the Short Form Health Survey. Emergent adverse reactions to treatment were recorded. Results: FIQ total scores decreased significantly during the study period, with the decrease being observed in the first 4 weeks of the study. Significant improvement was also seen both in depression scores and in the Physical Summary Score of the SF-12. Transient meteorism after ozone therapy sessions was the most frequently reported side-effect. Conclusions: At the dose and number of sessions used in this study, ozone therapy by rectal insufflation seems to be beneficial for physical symptoms and depression of fibromyalgia.Journal of alternative and complementary medicine (New York, N.Y.) 10/2012; · 1.69 Impact Factor