Oxygen-Ozone Therapy in Medicine: An Update

Department of Physiology, University of Siena, Siena, Italy.
Blood Purification (Impact Factor: 1.28). 09/2009; 28(4):373-6. DOI: 10.1159/000236365
Source: PubMed


Oxygen-ozone therapy, initially started as an empirical approach, has now reached a stage where most of the biological mechanisms of action of ozone have been clarified, showing that they are in the realm of orthodox biochemistry, physiology and pharmacology. Here we have reviewed a few relevant clinical applications and have shown that ozone therapy is particularly useful in cardiovascular disorders and tissue ischemia. In chronic viral infections, it is unable to eliminate the viremia but it may display supportive help by stimulating the immune system. Recently, its use has been successfully extended to the herniated disk pathology and therapy of primary caries in children.

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    • "It has been used in the water industry, disinfection of hospital rooms, dental unit water systems (Dyas et al. 1983; Bocci 1992; Berrington and Pedler 1998). Ozone therapy has been used for wound-healing improvement, immune system modulation and disinfection (Bocci and Di Paolo 2009), In dentistry, its use has been recommended for soft tissue healing during surgical procedures (Sandhaus 1969) and root caries treatment (Baysan et al. 2000). In blood, ozone disintegrates forming reactive oxygen species and lipid oxidation products that cause vasodilatation on the endothelium and release of prostacyclin, interleukin-8, nitric oxide, platelet-derived growth factors and transforming growth factor b, which play a major role in rapid wound healing (Bocci 1999). "
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    ABSTRACT: Unlabelled: This study aimed to compare the antimicrobial efficacy of low-temperature atmospheric pressure plasma (LTAPP) design and gaseous ozone delivery system with 2.5% NaOCl on Enterococcus faecalis in root canal walls and dentine tubules. The samples were divided into LTAPP (n = 12), ozone (n = 12), NaOCl (positive control, n = 12) and saline (negative control, n = 6) groups. Microbial samples were collected using paper points and dentin chips from root canals. Antimicrobial efficacy was assessed by counting the colony-forming units of Ent. faecalis before and after each irrigation protocol. Data were analysed using Kruskal-Wallis, Wilcoxon signed-rank, Friedman and Bonferroni t (Dunn's test)-tests (P = 0.05). The microbial sampling with paper points showed antibacterial efficacy of NaOCl, LTAPP, ozone and saline in descending order, respectively (P < 0.05). The microbial sampling with dentin chips demonstrated a superior efficacy of LTAPP compared with NaOCl in the middle third (P < 0.05), while both had similar effects in coronal and apical thirds (P > 0.05). NaOCl and LTAPP were better than ozone at the coronal and middle parts of the root canals (P < 0.05). These findings led us to suggest that LTAPP, which has no thermal and chemical effects, may be of great aid in endodontic treatment. Significance and impact of the study: The present study handles different perspectives on chemomechanical preparation of root canals. Ozone and low-temperature atmospheric pressure plasma (LTAPP) were investigated to determine whether they could be an alternative for NaOCl. Up to now, chemical solutions (NaOCl, chlorhexidine digluconate, etc...) have been used to disinfect the root canals. When the reported effects of LTAPP on biological and chemical decontamination were taken into consideration, a question rose whether it has antimicrobial efficacy in root canals infected with E. faecalis. According to the findings of the present study, LTAPP may constitute a promising aid in endodontics in disinfection of root canals.
    Letters in Applied Microbiology 08/2013; 58(1). DOI:10.1111/lam.12148 · 1.66 Impact Factor
    • "In our case, the nonhealing and necrotic wound seen postcompartment syndrome may be associated with continued tissue ischemia, reperfusion injury, and imbalanced tissue homeostasis and microcirculation.12 In blood, ozone almost immediately disintegrates forming reactive oxygen species and lipid oxidation products.311 The lipid oxidation products cause vasodilatation by acting on the endothelium, causing release of prostacyclin, interleukin-8, and nitric oxide.2313–15 "
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    ABSTRACT: Disinfectant and antibacterial properties of ozone are utilized in the treatment of nonhealing or ischemic wounds. We present here a case of 59 years old woman with compartment syndrome following surgical treatment of stress fracture of proximal tibia with extensively infected wound and exposed tibia to about 4/5 of its extent. The knee joint was also infected with active pus draining from a medial wound. At presentation the patient had already taken treatment for 15 days in the form of repeated wound debridements and parenteral antibiotics, which failed to heal the wound and she was advised amputation. Topical ozone therapy twice daily and ozone autohemotherapy once daily were given to the patient along with daily dressings and parenteral antibiotics. Within 5 days, the wound was healthy enough for spilt thickness skin graft to provide biological dressing to the exposed tibia bone. Topical ozone therapy was continued for further 5 days till the knee wound healed. On the 15(th) day, implant removal, intramedullary nailing, and latissimus dorsi pedicle flap were performed. Both the bone and the soft tissue healed without further complications and at 20 months follow-up, the patient was walking independently with minimal disability.
    Indian Journal of Orthopaedics 07/2011; 45(4):376-9. DOI:10.4103/0019-5413.80332 · 0.64 Impact Factor
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    ABSTRACT: Ozone has been successfully used in many fields of dentistry so far. Specifically in operative dentistry, it seems that can prevent the beginning and evolving of dental caries due to its proven antibactericidal properties. Although there is lack of organized data in in vitro and in vivo research activities, the use of such an operational device in a dental office could ideally contribute to the general philosophy of minimally invasive dental procedures. In dentistry the current way of using ozon is totally safe and technologically pioneer. The bigger acceptance of the device should be among phobic and young patients. But although promising in the beginning, the device does not have an extensive use in the everyday clinical practice. Despite this fact, the technological knowledge and the effectiveness of such a device have scientific interest. The purpose of this study is the description of all relevant information from in vivo and in vitro studies, concerning ozones use in operative dentistry and the evaluation of its effectiveness towards the treatment of dental caries.
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