A review on mouth dissolving films.

National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad. C/o. B.V. Patel Pharmaceutical Education and Research Development Centre, S.G. Highway, Thaltej, Ahmedabad-380054, India.
Current Drug Delivery (Impact Factor: 2.25). 09/2009; 6(5):469-76. DOI: 10.2174/156720109789941713
Source: PubMed

ABSTRACT The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however, patient compliance must not be overlooked. Fast dissolving drug delivery systems, such as, Mouth Dissolving Films (MDF), offer a convenient way of dosing medications, not only to special population groups with swallowing difficulties such as children and the elderly, but also to the general population. MDF are the novel dosage forms that disintegrate and dissolve within the oral cavity. Intra-oral absorption permits rapid onset of action and helps by-pass first-pass effects, thereby reducing the unit dose required to produce desired therapeutic effect. The present review provides an overview of various polymers that can be employed in the manufacture of MDF and highlights the effect of polymers and plasticizers on various physico-mechanical properties of MDF. It further gives a brief account of formulation of MDF and problems faced during its manufacture.

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    ABSTRACT: In this study, a novel orodispersible film (ODF) containing drug nanoparticles was developed with the goal of transforming drug nanosuspensions into a solid dosage form and enhancing oral bioavailability of drugs with poor water solubility. Nanosuspensions were prepared by high pressure homogenization and then transformed into ODF containing drug nanoparticles by mixing with hydroxypropyl methylcellulose solution containing microcrystalline cellulose, low substituted hydroxypropylcellulose and PEG-400 followed by film casting and drying. Herpetrione, a novel and potent antiviral agent with poor water solubility that extracted from Herpetospermum caudigerum, was chosen as a model drug and studied systematically. The uniformity of dosage units of the preparation was acceptable according to the criteria of Chinese Pharmacopoeia 2010. The ODF was disintegrated in water within 30 s with reconstituted nanosuspensions particle size of 280 ± 11 nm, which was similar to that of drug nanosuspensions, indicating a good redispersibility of the fast dissolving film. Result of X-ray diffraction showed that HPE in the ODF was in the amorphous state. In the in vitro dissolution test, the ODF containing HPE nanoparticles showed an increased dissolution velocity markedly. In the pharmacokinetics study in rats, compared to HPE coarse suspensions, the ODF containing HPE nanoparticles exhibited significant increase in AUC0-24h, Cmax and decrease in Tmax, MRT. The result revealed that the ODF containing drug nanoparticles may provide a potential opportunity in transforming drug nanosuspensions into a solid dosage form as well as enhancing the dissolution rate and oral bioavailability of poorly water-soluble drugs.
    European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 10/2013; · 3.15 Impact Factor
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    ABSTRACT: Mouth dissolving film becomes a novel approach to oral drug delivery system as it provides convenience and ease of use over other dosage forms such as orally disintegrating tablets buccal tablets and sublingual tablets, so mouth dissolving films are gaining the interest of large number of pharmaceutical industries. Mouth dissolving film was developed on the basis of technology of transdermal patch. Mouth dissolving films are thin solid dosage forms which when placed in the oral cavity; dissolve within few seconds without chewing and intake of water. The oral buccal mucosa being highly vascularized, drugs can absorbed directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism. This advantage can be exploited in preparing products with improved oral bioavailability of molecules that undergo first pass effect. These films offer convenient way of dosing medication to pediatric, geriatric and bedridden patients. The sublingual and buccal delivery of a drug via thin film has the potential to improve the onset of action, lower the dosing and enhance the efficacy and safety profile of medicament. An ideal film should have the properties like pleasant taste, high stability and ease of handling. Present review provides an account of various formulation methods and their evaluation used in film formulations and applications of mouth dissolving film.
    International Journal of Pharma Research & Review. 10/2013; 2(10):41-47.
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    ABSTRACT: Recently, fast dissolving films are gaining interest as an alternative of fast dissolving tablets. The films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and increased patient compliance. As the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided. These points make this formulation most popular and acceptable among pediatric and geriatric patients and patients with fear of choking. Over-the-counter films for pain management and motion sickness are commercialized in the US markets. Many companies are utilizing transdermal drug delivery technology to develop thin film formats. In the present review, recent advancements regarding fast dissolving buccal film formulation and their evaluation parameters are compiled.
    International journal of pharmaceutical investigation. 01/2013; 3(2):67-76.


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May 17, 2014