Article

Development of light-responsive BNA toward the spatiotemporal control of gene expression.

Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.
Nucleic Acids Symposium Series 01/2009; DOI:10.1093/nass/nrp094 pp.187-8
Source: PubMed

ABSTRACT We designed and synthesized light-responsive BNA (bridged nucleic acid), which has a photolabile group at the bridged structure. Light-Responsive BNA can change its structure by a two stages process: photoirradiation followed by nucleophilic treatment. In oligonucleotides containing light-responsive BNA moieties, binding affinity with complementary single-stranded RNA was lost upon photoirradiation, but could be restored by nucleophilic treatment.(1)

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Keywords

binding affinity
 
bridged nucleic acid
 
bridged structure
 
complementary single-stranded RNA
 
Light-Responsive BNA
 
light-responsive BNA moieties
 
nucleophilic treatment
 
synthesized light-responsive BNA
 
two stages process
 

Kunihiko Morihiro