Article

Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediates.

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan.
Nucleic Acids Symposium Series 01/2009; DOI:10.1093/nass/nrp005 pp.9-10
Source: PubMed

ABSTRACT P-Stereodefined oligodeoxyribonucleoside boranophosphates (PB-ODNs) were successfully synthesized by the conversion of diastereopure H-phosphonate intermediates. Thermal denaturation studies clearly showed that the duplex stability of PB-ODNs with the complementary DNA and RNA depends on the stereochemistry of the boranophosphate linkages.

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Keywords

boranophosphate linkages
 
complementary DNA
 
diastereopure H-phosphonate intermediates
 
P-Stereodefined oligodeoxyribonucleoside boranophosphates
 
Thermal denaturation studies
 

Naoki Iwamoto