Intravenous aminobisphosphonates for managing complications of malignant osteolysis in companion animals.
ABSTRACT Aminobisphosphonates are a class of drugs effectively used for the management of pathologic skeletal conditions in people, most notably hormonally mediated osteoporosis and cancer-associated bone metastases. Based on their physicochemical properties, aminobisphosphonates concentrate within areas of active skeletal remodeling and exert protective bone biologic effects through the induction of osteoclast apoptosis. Given the similar mineral composition and cellular components of bone tissue shared among mammals, it would be expected that aminobisphosphonates should also be effective in managing malignant bone diseases in dogs and cats. The first half of this review article briefly summarizes the general properties of aminobisphosphonates including their pharmacology, mechanism of action, and potential adverse side effects. The second half of this review focuses on the clinical utility of aminobisphosphonates and measures of response in dogs and cats diagnosed with malignant skeletal tumors.
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ABSTRACT: PRACTICAL RELEVANCE: Musculoskeletal neoplasia is an uncommon but Important differential diagnosis for cats presenting with lameness, pain or swellings associated with bones and/or soft tissues. The most common tumours of soft tissue origin are the sarcomas (in particular feline injection site sarcomas [FISSs]); the most common bone tumour of the cat is osteosarcoma (OSA). CLINICAL CHALLENGES: FISSs present a clinical challenge in terms of their local invasiveness, difficulty in obtaining complete surgical excision and high risk of local recurrence. Axial and extraskeletal OSAs pose similar challenges, whereas appendicular OSA is usually easy to remove via limb amputation and can, therefore, carry a good prognosis in many cases. PATIENT GROUP: Cats of any age, gender or breed may be affected, although bone tumours predominantly affect middle- to old-aged cats. GLOBAL IMPORTANCE: Vaccination of cats is of global importance in preventing feline diseases; hence, any possible significant consequences of vaccination such as neoplasia, even of a low incidence, are of huge concern to cat owners and veterinarians alike. EVIDENCE BASE: This review is based on current literature relating to pathogenesis, pathology, presentation, diagnosis, staging, treatment and prognosis. It aims to summarise feline musculoskeletal neoplasia for clinicians in general practice.Journal of feline medicine and surgery. 01/2012; 14(1):43-54.
Conference Paper: Morphological detection algorithm of an event on board a ship[Show abstract] [Hide abstract]
ABSTRACT: In this paper, two novel morphological event detection algorithms are proposed for a vision based warning system, in consideration of a situation such as camera trembling on board a ship. Under such camera trembling, edge-like streaks appear on the difference image and so it is not adequate to use the statistics of the difference image directly for event detection. The proposed algorithms, based on the difference image, exploit morphological filters to sequentially threshold images so as to remove the edge-like components of the difference image, while keeping the vestige of events. The simulation results show a good performance robust to camera tremblingSignal Processing Proceedings, 1998. ICSP '98. 1998 Fourth International Conference on; 02/1998