Article

[An improved liquid nitrogen freezing method for establishing canine models of femoral head necrosis].

Department of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 09/2009; 29(8):1602-4.
Source: PubMed

ABSTRACT To establish an canine model of femoral head osteonecrosis using an improved liquid nitrogen freezing method.
Sixteen adult canines were divided into 4 groups at random and subjected to instant freezing of the unilateral femoral head with liquid nitrogen. The dogs were observed at 2, 4, 8, and 16 weeks after the operation for radiographic, gross and pathological changes of the femoral head.
Significant radiographic, gross and pathological changes occurred in the femoral head after the freezing.
Improved liquid nitrogen freezing of the femoral head provides a simple and convenient method for establishing animal models of femoral head osteonecrosis.

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Keywords

4 groups
 
adult canines
 
animal models
 
convenient method
 
femoral head
 
femoral head osteonecrosis
 
gross
 
Improved liquid nitrogen freezing
 
improved liquid nitrogen freezing method
 
instant freezing
 
liquid nitrogen
 
random
 
unilateral femoral head