Cylindroma of the breast: a case report and review of the literature

BreastCheck, National Cancer Screening Service/Mercy University Hospital, Cork, Ireland.
Diagnostic Pathology (Impact Factor: 2.6). 10/2009; 4(1):30. DOI: 10.1186/1746-1596-4-30
Source: PubMed


Cylindroma of the breast is a very rare lesion which is morphological and immunophenotypically identical to benign dermal cylindroma. We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations, smaller peripheral basaloid cells and larger central cells with vesicular chromatin, were highlighted by immunohistochemistry for p63 and cytokeratin-7 respectively. Immunohistochemistry for ER, PR, and Her2/neu was negative in tumour cells. We discuss the nine previously reported cases and the distinction of breast cylindroma from adenoid cystic carcinoma, the main differential diagnosis.

Download full-text


Available from: Amr Mahmoud, Mar 31, 2015

  • Indian Journal of Pathology and Microbiology 01/2011; 54(1):204-5. DOI:10.4103/0377-4929.77407 · 0.47 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Epithelial-myoepithelial proliferations of the breast are a heterogeneous poorly defined group of lesions characterized morphologically by dual differentiation into ductal (luminal) and myoepithelial cells. They include neoplastic and non-neoplastic entities that have overlapping morphologic features that may give rise to diag- nostic difficulty. Many of these entities are low grade or of uncertain malignant potential but the biology of some of these rare lesions remains to be elucidated. This article discusses the differen- tial diagnosis of epithelial-myoepithelial lesions of the breast and highlights the morphologic features of some of these entities.
    Surgical Pathology Clinics 09/2012; 5:661-699. DOI:10.1016/j.path.2012.06.003
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cylindroma is a benign adnexal tumor, which occurs as solitary dermal nodules on the scalp and forehead. Cylindroma of the breast is a rare lesion. Fine-needle aspiration is often the first line of investigation. In this communication, we illustrate the cytomorphological feature of cylindroma in a 61-year-old female patient who presented with a breast lump. Fine-needle aspiration cytology in this case reveals the islands of tumor cells formed a "jig-saw" pattern, along with the bland, basaloid cells associated with globular, extracellular material. These features are typical of cylindroma, but differential diagnosis of adenoidcystic carcinoma should always be kept in mind as the management of both tumors are different.
    International Journal of Trichology 04/2013; 5(2):83-85. DOI:10.4103/0974-7753.122967
Show more