Article

Synthesis of a neonicotinoide pesticide derivative via chemoenzymatic dynamic kinetic resolution.

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
The Journal of Organic Chemistry (Impact Factor: 4.56). 10/2009; 74(19):7407-10. DOI:10.1021/jo9014276
Source: PubMed

ABSTRACT Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).

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