Article

[Current panorama in the diagnosis of cutaneous tuberculosis].

Departamento de Dermatología, Hospital Universitario Dr. José Eleuterio González, UANL, Monterrey, México.
Actas Dermo-Sifiliográficas 10/2009; 100(7):562-70. pp.562-70
Source: PubMed

ABSTRACT Pulmonary and cutaneous tuberculosis are caused by Mycobacterium tuberculosis. According to data from the World Health Organization, there are around 8 million new cases per year.The incidence of cutaneous tuberculosis has risen in parallel with that of pulmonary tuberculosis, and coinfection by M tuberculosis and human immunodeficiency virus is considered to be one of the main causes. Current diagnostic methods for pulmonary and extrapulmonary tuberculosis are far from perfect, leading to a delay in starting appropriate therapy.We present a review of these diagnostic methods and of their use in the cutaneous forms. In conclusion,histopathologic findings and isolation of M tuberculosis in cultures of biopsy material or by polymerase chain reaction are the most useful diagnostic tools in cutaneous tuberculosis.

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    Article: Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovis in the aortic tissue of patients with Takayasu's arteritis.
    Maria Elena Soto, Maria Del Carmen Avila-Casado, Claudia Huesca-Gomez, Gilberto Vargas-Alarcon, Vicente Castrejon, Virgila Soto, Sergio Hernandez, Maite Vallejo, Pedro A Reyes, Benito Chavez-Renteria, Nilda Espinola-Zavaleta, Ricardo Gamboa
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    ABSTRACT: Takayasu's arteritis (TA) is a chronic inflammatory disease affecting the large arteries and their branches; its etiology is still unknown. In individuals suffering from TA, arterial inflammation progresses to stenosis and/or occlusion, leading to organ damage and affecting survival. Relation of TA with Mycobacterium tuberculosis has been known, but there have been only a few systematic studies focusing on this association. The IS6110 sequence identifies the Mycobacterium tuberculosis complex and the HupB establishes the differences between M. tuberculosis and M. bovis. Our objective was to search the presence of IS6110 and HupB genes in aorta of patients with TA. METHODS: We analyzed aorta tissues embedded in paraffin from 5760 autopsies obtained from our institution, we divided the selected samples as cases and controls; Cases: aortic tissues of individuals with Takayasu's arteritis. Control positive: aortic tissues (with tuberculosis disease confirmed) and control negative with other disease aortic (atherosclerosis). RESULTS: Of 181 selected aorta tissues, 119 fulfilled the corresponding criteria for TA, TB or atherosclerosis. Thus 33 corresponded to TA, 33 to tuberculosis (TB) and 53 to atherosclerosis. The mean age was 22?±?13, 41?±?19, and 57?±?10, respectively. IS6110 and HupB sequences were detected in 70% of TA tissues, 82% in tuberculosis, and in 32% with atherosclerosis. Important statistical differences between groups with TA, tuberculosis versus atherosclerosis (p?=?0.004 and 0.0001, respectively) were found. CONCLUSION: We identified a higher frequency of IS6110 and HupB genes in aortic tissues of TA patients. This data suggests that arterial damage could occur due to previous infection with M. tuberculosis.
    BMC Infectious Diseases 08/2012; 12(1):194. · 3.12 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

8 million new cases
 
appropriate therapy.We present
 
biopsy material
 
Current diagnostic methods
 
cutaneous forms
 
cutaneous tuberculosis
 
diagnostic methods
 
extrapulmonary tuberculosis
 
human immunodeficiency virus
 
M tuberculosis
 
main causes
 
Mycobacterium tuberculosis
 
perfect
 
polymerase chain reaction
 
Pulmonary
 
pulmonary tuberculosis
 
useful diagnostic tools
 
World Health Organization