Inherited susceptibility to pediatric acute lymphoblastic leukemia

Nature Genetics (Impact Factor: 29.35). 10/2009; 41(9):957-8. DOI: 10.1038/ng0909-957
Source: PubMed


Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis.

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    • "This allows application of genomic strategies similar to those used in humans such as subclassification of tumors according to gene expression patterns [4]. Furthermore, naturally occurring DNA polymorphisms can help identify variants that influence lymphoma development or progression, thereby providing genetic clues for understanding disease biology [8]. An additional advantage is that canine lymphomas are an excellent model of chemoresistant disease. "
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