Article

A new effective scaffold to facilitate peripheral nerve regeneration: chitosan tube coated with maggot homogenate product.

Department of Orthopedic Surgery, First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province, China.
Medical Hypotheses (impact factor: 1.39). 09/2009; 74(1):12-4. DOI:10.1016/j.mehy.2009.07.053 pp.12-4
Source: PubMed

ABSTRACT Recent efforts in scientific research in the field of peripheral nerve regeneration have been directed towards the development of artificial nerve guides. Chitosan tubes applied as a biocompatible and biodegradable bilateral guide for nerve repair is a hot spot in research to date. In previous study, we have found the homogenate product from disinfected maggot larvae can promote wound nerve regeneration and neuropeptides release. Wound nerves belong to the peripheral nerve system. We thus hypothesize that maggot homogenate product use as an external layer outside the chitosan tube will be an effective therapy to facilitate peripheral nerve regeneration.

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Keywords

artificial nerve guides
 
biocompatible
 
biodegradable bilateral guide
 
chitosan tube
 
Chitosan tubes
 
disinfected maggot larvae
 
effective therapy
 
homogenate product
 
maggot homogenate product use
 
peripheral nerve regeneration
 
peripheral nerve system
 
Recent efforts
 
wound nerve regeneration
 
Wound nerves
 

Zhen Zhang