Recent efforts in scientific research in the field of peripheral nerve regeneration have been directed towards the development of artificial nerve guides. Chitosan tubes applied as a biocompatible and biodegradable bilateral guide for nerve repair is a hot spot in research to date. In previous study, we have found the homogenate product from disinfected maggot larvae can promote wound nerve regeneration and neuropeptides release. Wound nerves belong to the peripheral nerve system. We thus hypothesize that maggot homogenate product use as an external layer outside the chitosan tube will be an effective therapy to facilitate peripheral nerve regeneration.
"Using remittance spectroscopy to evaluate patients before and after maggot therapy, Wollina and colleagues  found that vascular perfusion and tissue oxygenation surrounding the wound actually increased following maggot therapy. Zhang and colleagues  are currently seeing evidence that maggot extracts may even stimulate the growth of neural tissue. Early clinical reports of maggot-induced wound healing were merely case studies or series; but beginning in the 1990's, controlled comparative trials of maggot therapy began to appear. "
[Show abstract][Hide abstract] ABSTRACT: MEDICINAL MAGGOTS ARE BELIEVED TO HAVE THREE MAJOR MECHANISMS OF ACTION ON WOUNDS, BROUGHT ABOUT CHEMICALLY AND THROUGH PHYSICAL CONTACT: debridement (cleaning of debris), disinfection, and hastened wound healing. Until recently, most of the evidence for these claims was anecdotal; but the past 25 years have seen an increase in the use and study of maggot therapy. Controlled clinical studies are now available, along with laboratory investigations that examine the interaction of maggot and host on a cellular and molecular level. This review was undertaken to extract the salient data, make sense, where possible, of seemingly conflicting evidence, and reexamine our paradigm for maggot-induced wound healing. Clinical and laboratory data strongly support claims of effective and efficient debridement. Clinical evidence for hastened wound healing is meager, but laboratory studies and some small, replicated clinical studies strongly suggest that maggots do promote tissue growth and wound healing, though it is likely only during and shortly after the period when they are present on the wound. The best way to evaluate-and indeed realize-maggot-induced wound healing may be to use medicinal maggots as a "maintenance debridement" modality, applying them beyond the point of gross debridement.
Evidence-based Complementary and Alternative Medicine 03/2014; 2014(2):592419. DOI:10.1155/2014/592419 · 1.88 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A general introduction to tissue engineering and chitosan as well as its applications in hard tissues has been given in the first part of this review which is previously published in this journal. In this second part, applications of chitosan based systems for the soft tissue engineering will be reviewed. Due to the its properties such as biocompatibility, biodegradability, bioadhesivity as well as its bioactive properties wound healing effect, homeostasis, and antimicrobial activity, chitosan it is a promising scaffold material for tissue engineering. After a brief introduction to tissue engineering in soft tissues such as skin, adipose, cornea, liver, nerve and blood vessel, the application of chitosan for regeneration of these tissues will be discussed in regard to formulation of scaffolds. The strategies to improve their efficacy will also be mentioned. INTRODUCTION Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences in order to fabricate living replacement parts for the body (1). The most common approach for tissue engineering is utilization of scaffolds which are artificial structures capable of stimulating cellular growth, proliferation and cellular differentiation.
[Show abstract][Hide abstract] ABSTRACT: As the field of nerve tissue engineering advances, new biomaterials and structures are required to improve the regeneration of damaged nerves. Carbon nanostructures have been recognized as potential candidates to develop neural prostheses due to their one-dimensional nanostructures and similar nanoscale dimensions to neuritis as well as their unique electrical and mechanical properties when being used as a scaffold. This review addresses the promising application of carbon nanostructures in the repair of injured nerves. As a new viewpoint, the possibility of utilizing carbon nanostructures to repair a long gap in a severed nerve will be discussed as well.
Ceramics International 04/2012; 38(8):6075-6090. DOI:10.1016/j.ceramint.2012.05.038 · 2.61 Impact Factor
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