Article

Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia.

Institute of Hematology, Medical School, 11000 Belgrade, Serbia.
Journal of Genetics (impact factor: 1.09). 09/2009; 88(2):149-52. pp.149-52
Source: PubMed

ABSTRACT Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.

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Keywords

426 consecutive AML patients
 
chemotherapy
 
de novo acute myeloid leukemia
 
FLT3/ITD mutation
 
immunophenotype pattern
 
molecular analyses
 
near-tetraploidy
 
near-tetraploidy/tetraploidy
 
patients
 
tumour suppressor gene
 
tyrosine kinase receptor FLT3 gene
 
variable clinical course