Single institute study of FLT3 mutation in acute myeloid leukemia with near tetraploidy in Serbia.
ABSTRACT Patients with de novo acute myeloid leukemia (AML) and near-tetraploid or completely tetraploid karyotype at presentation are rare. We present four patients with near-tetraploidy/tetraploidy in a cohort of 426 consecutive AML patients (0.98%) in respect to their cytogenetic findings, immunophenotype pattern, response to chemotherapy, course of disease and molecular analyses including tyrosine kinase receptor FLT3 gene, NRAS gene, and tumour suppressor gene, p53. We have found FLT3/ITD mutation only in one patient among the four with near-tetraploidy. The main finding is that these patients had a variable clinical course, with two having a long period of remission (36 and 12 months) and two died, not having achieved remission.
[Show abstract] [Hide abstract]
ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by specific morphology, immunophenotype and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which are now widely recognized as one of the most important diagnostic and prognostic determinants in AML. Here, we present a case with unusual cytogenetics, which has been described in very few patients.Journal of cancer research and therapeutics 01/2014; 10(1):187-90. DOI:10.4103/0973-1482.131406 · 0.95 Impact Factor
Annals of Laboratory Medicine 09/2013; 33(5):371-4. DOI:10.3343/alm.2013.33.5.371 · 1.48 Impact Factor