Utility of Waist-To-Height Ratio in Detecting Central Obesity and Related Adverse Cardiovascular Risk Profile Among Normal Weight Younger Adults (from the Bogalusa Heart Study)
ABSTRACT Data on the utility of the waist-to-height ratio in detecting central obesity and related cardiovascular risk among normal weight younger adults are scant. This aspect was examined in 639 normal weight (body mass index 18.5 to 24.9 kg/m(2)) black and white adults (75% white and 36% men) 20 to 44 years old. The subjects with a waist-to-height ratio > or =0.5 were grouped as having central obesity normal weight, with the rest considered the control group. The subjects with central obesity, compared to the controls, after adjusting for age, race, and gender, had significantly greater diastolic blood pressure, mean arterial pressure, low-density lipoprotein cholesterol level, triglycerides, triglycerides/high-density lipoprotein cholesterol ratio, insulin, homeostasis model assessment of insulin resistance, uric acid, C-reactive protein, and liver function enzymes (alanine aminotransferase and gamma-glutamyl transferase). On multivariate analysis, the central obesity group compared to the control group was 1.9, 2.2, 2.9, and 2.5 times more likely to have significantly adverse levels (top tertile vs the rest) of mean arterial pressure, triglycerides/high-density lipoprotein cholesterol ratio, homeostasis model assessment of insulin resistance, and C-reactive protein, respectively. The central obesity group also had a greater prevalence of dyslipidemia, hypertension, insulin resistance, hyperuricemia, and elevated C-reactive protein. The age-, race-, and gender-adjusted mean value of the common carotid intima-media thickness, a measure of subclinical atherosclerosis, was greater in the central obesity group compared to the control group (0.76 vs 0.71 mm, p = 0.009). In conclusion, these findings underscore the utility of the waist-to-height ratio in detecting central obesity and related adverse cardiovascular risk among normal weight younger adults.
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- "Hsieh et al. pointed out that the relative amount of central fat may be more closely associated with metabolic risks than the absolute amount of central fat among a population with moderate BMI, and WC adjusted by height may better reflect the combined metabolic risks (Hsieh et al. 2010). Srinivasan et al. (2009) "
ABSTRACT: There is little consensus on the best obesity index associated with metabolic risk factors among the population with normal both body mass index (BMI) and waist circumference (WC). We therefore evaluated the association between anthropometric indices and metabolic risk factors in a Korean population with normal BMI and WC. This cross-sectional study involved 2,952 participants aged 20-79 years who had normal BMI and WC, based on the Fourth Korea National Health and Nutrition Examination Surveys conducted in 2008. The receiver operating characteristic (ROC) curves were generated to identify the optimal measurement of obesity for the prediction of metabolic risk factors in this population. The area under the ROC curve value for waist-to-height ratio (WHtR) in prediction of metabolic syndrome (MetS) and its components was higher than that for BMI and WC. Among individuals with normal BMI and WC, prevalence of all metabolic risk factors and MetS significantly increased across the quartiles of WHtR in both men and women. After adjustment for potential confounders, the Odds Ratios (95% confidence intervals) for MetS in the second, third, and fourth quartiles of WHtR compared to the first quartile of WHtR were 3.53 (2.12-5.89), 6.06 (3.52-10.43), and 7.11 (4.08-12.38) in men, and 1.66 (1.01-2.72), 2.79 (1.81-4.30), and 2.82 (1.76-4.52) in women, respectively. In conclusion, WHtR has the best predictive value for evaluating the metabolic risk factors compared to BMI or WC alone among subjects with normal BMI and WC.The Tohoku Journal of Experimental Medicine 09/2012; 228(1):1-8. DOI:10.1620/tjem.228.1 · 1.28 Impact Factor
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ABSTRACT: Studies of incorporation of C14-labeled acetate into MPS, hyaluronic acid and chondroitin sulfate from skin and chondroitin sulfate from cartilage of rabbits with and without serum sickness, indicated little difference effected by serum sickness. Specific activities of skin MPS were possibly increased. Greater incorporation of the isotope was observed in liver and muscle glycogen from rabbits with serum sickness. Further study of other hypersensitivity reactions and of tissues more specifically involved by such reactions need investigation. Such experiments, currently in progress utilizing the local Shwartzman lesion, do indicate a considerable increase of metabolic activity of the MPS.Proceedings of The Society for Experimental Biology and Medicine 06/1959; 101(1):26-8. DOI:10.3181/00379727-101-24820
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ABSTRACT: We propose a scheme combining transmit antenna selection and maximal-ratio combining (MRC) at the receiver. In this scheme L antennas are chosen for transmission among all available transmit antennas N and maximal-ratio combining is performed at the receiver side. The pairwise error probability (PEP) of the scheme is derived in quasistatic Rayleigh fading channels. The analysis and simulation results show that, after L transmit antennas selection among all N available transmit antennas, though the diversity order is decreased to a certain extent, more diversity gain can still be obtained with our scheme compared with the case of no antenna selection, i.e. (L;M). And, this scheme significantly outperforms the space-time codes of the same diversity order with the same spectral efficiency.Emerging Technologies: Frontiers of Mobile and Wireless Communication, 2004. Proceedings of the IEEE 6th Circuits and Systems Symposium on; 01/2004