The serotonin transporter gene polymorphism (5-HTTLPR) and affective symptoms among women diagnosed with borderline personality disorder
ABSTRACT Gene variants of the serotonin transporter have been associated with vulnerability to affective disorders. In particular, the presence of one or two copies of the short (s) allele of the 5-HTTLPR polymorphism has been associated with reduced serotonin transporter expression and function, and vulnerability to affective disorders. To test for an association between variants of the serotonin transporter gene polymorphism (5-HTTLPR) and relevant clinical features of borderline personality disorder (BPD), a psychiatric disorder with symptoms characteristic for serotonin dysfunction, 77 women with BPD were genotyped in the 5-HTTLPR polymorphism. They rated their subjective experience of borderline-specific, depressive, anxious and obsessive-compulsive symptoms, and were interviewed about lifetime incidence of suicide attempts and self-harming acts. Carriers of two s alleles of the 5-HTTLPR reported more symptoms of borderline, depression, anxiety and obsessive-compulsive behaviours, but not of suicidal and self-injury behaviour, compared to carriers of a long (l) allele. This indicates that the 5-HTTLPR ss homozygous genotype might influence serotonin function affecting susceptibility to both borderline-specific, depressive, anxious and obsessive-compulsive symptoms in BPD, and leading to a more severe symptomatology related to these clinical features. Further, this suggests that 5-HTT gene variants may not be as influential on suicidal and self-injury behaviour in BPD.
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- "Family, adoption and twin studies demonstrate that genetics play a role in suicidal behavior . In fact, the influence of genetic variants on human behavior may be relevant to the symptomatology involved in psychiatric disorders . For instance, genetic variants in the serotonin transporter have been associated with vulnerability to affective disorders. "
ABSTRACT: The aim of the present study was to analyze if the genetic polymorphisms might predict suicide attempts in mental disorder patients. The literature review and meta-analysis were conducted using the PubMed/Medline, Web of science and Scopus database using the terms: "5-HTT or SLC6A4 or 5-SERT and suicide, suicidal ideation or suicidal behavior or suicidal attempt". Thirty articles were analyzed. We found 17 articles that showed association and 13 articles that showed no association between LPR serotonin transporter polymorphism and suicide. A higher study of suicide identified the serotonin transporter polymorphism in patients with schizophrenia, mental disorder, major depression and bipolar disorder. There is an association between the serotonin-transporter-linked polymorphic region and suicidal behavior. The mental disorders with greater relationship with the suicide were the bipolar disorder, major depression and schizophrenia. The L allele had higher risk for suicide.CNS & neurological disorders drug targets 07/2015; 14(7). DOI:10.2174/1871527314666150713104619 · 2.70 Impact Factor
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- "In addition to homozygous SERT −/− rats and mice (which display overt developmental and behavioral deficits; Holmes et al., 2003b; Homberg et al., 2007; Kalueff et al., 2010; Murphy and Lesch, 2008), SERT +/− rodents also show altered emotional and motor behaviors, as well as increased sensitivity to various experimental manipulations (Ansorge et al., 2004; Fox et al., 2007; Moya et al., 2011; Murphy and Lesch, 2008). Their 50% decrease in transporter activity (Fox et al., 2009; Snoeren et al., 2010) resembles polymorphisms in the human SERT gene (Hu et al., 2006; Lesch et al., 1996; Maurex et al., 2010; Praschak-Rieder et al., 2007), especially the well-studied human SERT-linked promoter region (5HTT-LPR, consisting of the 'active' L allele and the 'less active' S allele), which is strongly implicated in multiple behavioral syndromes (Blom et al., 2011; Kuzelova et al., 2010; Nikolas et al., 2010). BDNF is crucial for various brain processes, including cell differentiation and survival, axonal growth, neurogenesis and memory formation (Acheson et al., 1995; Bekinschtein et al., 2008; Cheng et al., 2011; Pencea et al., 2001), acting via tyrosine kinase B (TrkB) and p75 receptors. "
ABSTRACT: Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key modulators of molecular signaling, cognition and behavior. Although SERT and BDNF mutant mouse phenotypes have been extensively characterized, little is known about their self-grooming behavior. Grooming represents an important behavioral domain sensitive to environmental stimuli and is increasingly used as a model for repetitive behavioral syndromes, such as autism and attention deficit/hyperactivity disorder. The present study used heterozygous ((+/-)) SERT and BDNF male mutant mice on a C57BL/6J background and assessed their spontaneous self-grooming behavior applying both manual and automated techniques. Overall, SERT(+/-) mice displayed a general increase in grooming behavior, as indicated by more grooming bouts and more transitions between specific grooming stages. SERT(+/-) mice also aborted more grooming bouts, but showed generally unaltered activity levels in the observation chamber. In contrast, BDNF(+/-) mice displayed a global reduction in grooming activity, with fewer bouts and transitions between specific grooming stages, altered grooming syntax, as well as hypolocomotion and increased turning behavior. Finally, grooming data collected by manual and automated methods (HomeCageScan) significantly correlated in our experiments, confirming the utility of automated high-throughput quantification of grooming behaviors in various genetic mouse models with increased or decreased grooming phenotypes. Taken together, these findings indicate that mouse self-grooming behavior is a reliable behavioral biomarker of genetic deficits in SERT and BDNF pathways, and can be reliably measured using automated behavior-recognition technology.Brain research bulletin 08/2012; 89(5-6):168-76. DOI:10.1016/j.brainresbull.2012.08.004 · 2.97 Impact Factor
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ABSTRACT: Photocatalytic oxidation of cyanide in water was studied. In the presence of P25, cyanate was produced prior to the other products, and nitrate was mainly formed as the cyanate decomposed Photo-oxidation of cyanide occurred even without dissolved oxygen suggesting that water molecule could be a source of oxygen. Tungstophosphoric acid-modified titania (TPA/TiO2) showed better activity than the corresponding pure titania. In the presence of OH⊙ scavenger such as isopropyl alcobol and bromide, the activity of TPA/TiO2 was retarded less than that of pure titania suggesting that the possibility of another reaction mechanism, probably direct oxidation by electron transfer.Studies in surface science and catalysis 01/2003; 145:161-164. DOI:10.1016/S0167-2991(03)80185-4