Angiosarcoma Arising in Mature Cystic Teratoma of the Ovary: A Case Report and Review of the Literature

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists (Impact Factor: 1.63). 10/2009; 28(5):453-7. DOI: 10.1097/PGP.0b013e31819d4574
Source: PubMed

ABSTRACT Mature cystic teratoma of the ovary is the most common ovarian tumor. Malignant transformation of this neoplasm is rare and is mostly represented by squamous carcinoma. Less frequently, malignant transformation is represented by a sarcoma. To date, only 5 cases of angiosarcoma arising in a mature cystic teratoma of the ovary have been reported. Herein, we report the clinicopathologic features of one such case. A review of the literature is also presented.

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    • "In contrast to angiosarcoma of the breast, primary ovarian angiosarcoma is relatively rare, with the largest series describing seven cases [19]. Angiosarcomas of the ovary may be pure or admixed with (or can arise from) other neoplasms, commonly teratomas, as well as adenocarcinomas and fibromas [20] [21] [22] [23]. Although there is a wide age range, similarly to primary breast angiosarcomas, most patients with ovarian angiosarcomas present at child bearing age (albeit the upper limit, with a median age of 42) [19] [24]. "
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    ABSTRACT: Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.
    10/2010; 2010:842592. DOI:10.4061/2010/842592
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