Angiosarcoma Arising in Mature Cystic Teratoma of the Ovary: A Case Report and Review of the Literature

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists (Impact Factor: 1.67). 10/2009; 28(5):453-7. DOI: 10.1097/PGP.0b013e31819d4574
Source: PubMed


Mature cystic teratoma of the ovary is the most common ovarian tumor. Malignant transformation of this neoplasm is rare and is mostly represented by squamous carcinoma. Less frequently, malignant transformation is represented by a sarcoma. To date, only 5 cases of angiosarcoma arising in a mature cystic teratoma of the ovary have been reported. Herein, we report the clinicopathologic features of one such case. A review of the literature is also presented.

13 Reads
  • Source
    • "In contrast to angiosarcoma of the breast, primary ovarian angiosarcoma is relatively rare, with the largest series describing seven cases [19]. Angiosarcomas of the ovary may be pure or admixed with (or can arise from) other neoplasms, commonly teratomas, as well as adenocarcinomas and fibromas [20] [21] [22] [23]. Although there is a wide age range, similarly to primary breast angiosarcomas, most patients with ovarian angiosarcomas present at child bearing age (albeit the upper limit, with a median age of 42) [19] [24]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years later. Only two confirmed primary angiosarcomas of the breast metastasizing specifically to the ovary have been described in the literature. However, all previous cases had ovarian metastases at presentation or shortly after initial diagnosis. This case is unusual as it occurred after a relatively long interval, and apparently developed during pregnancy. We discuss this rare phenomenon, as well as the possible factors contributing to the recurrence.
    Case Reports in Oncological Medicine 12/2013; 2013:209610. DOI:10.1155/2013/209610
  • Source
    • "Metastases to the ovary from soft tissue AS rarely occur [8,9]. 60% of all reported AS were detected in stage III and IV [1-4,6,10-18]. Surgical debulking and chemotherapy provided only short disease-free intervals, and most patients died from lung metastasis within 9 months. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Primary angiosarcoma of the ovary (AS) is a rare entity with only 31 reported cases. The majority are pure angiosarcomas, the remainder are associated either with teratomas or conventional epithelial tumors. More than 50% of ovarian AS are disseminated at the time of diagnosis, the minority is detected in stage I. The prognosis of ovarian angiosarcoma in general is poor. Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient. Virtual Slides The virtual slide(s) for this article can be found here:
    Diagnostic Pathology 07/2011; 6(1):65. DOI:10.1186/1746-1596-6-65 · 2.60 Impact Factor
  • Source
    • "Cytokeratin is expressed in about one third of soft tissue angiosarcomas. Immunopositivity to actin and laminin can be found too [2, 4, 5, 10, 13–17]. The features correlated with poor outcome include older age, invasion of adjacent structures, large size, and high Ki67 values [9]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.
    Pathology Research International 10/2010; 2010(4):842592. DOI:10.4061/2010/842592
Show more