Malignant fibrous histiocytoma of larynx with giant cell: case report and histological-clinical considerations.

ENT Department, University of Medicine and Pharmacy of Craiova, Romania.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (Impact Factor: 0.72). 02/2009; 50(3):481-5.
Source: PubMed

ABSTRACT Malignant fibrous histiocytoma (MFH) is a tumor which has a mesenchymal origin, and an uncertain histogenesis. MFH with giant cell accounts for 3-15% of all malignant fibrous histiocytomas.
To explore the histopathology, the diagnosis and the treatment of MFH with giant cell of larynx.
We report a case of a glottic MFH at a 59-year-old male, who has been smoking for 30 years, and was hospitalized in June 2008 at Emergency County Hospital of Craiova.
The largely-sized tumor was originated in glottic area, upper a left vocal cord, with no paresis. The tumor determined respiratory failure and dysphonia. Patient underwent surgical excision of the tumor after an emergency tracheotomy. The immunohistochemical techniques proved positive for vimentin, smooth muscle actin, CD68, CD34, bcl2, EGFR, S100, Ki67, and negative for CD117, NFT, chromogranin, c-erbB2, CK34betaE12, MNF116, and p53.
Malignant fibrous histiocytomas (MFH) with giant cell of larynx are very rare mesenchymal neoplasm (this case seems the first reported). The diagnosis of MFH of larynx was difficult and the immunohistochemistry could have been helpful.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Laryngeal presentation of Malignat Fibrous Histiocytoma (MFH) is uncommon. It is more prevalent in elderly males. The most frequent form of laryngeal presentation is as subepithelial nodules, and its clinical behaviour is variable and unpredictable. Microscopically, it is a tumour with two well differentiated components: histiocitic and fibroblastic, with several different structural patterns that can make histologic diagnosis a difficult one. We present two cases of MFH of the larynx, and a review of the literature.
    Acta Otorrinolaringológica Española 11/2004; 55(8):390-4.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This is the first case report of malignant fibrous histiocytoma of the hypopharynx in a young adult with preservation of the larynx. Although the initial histopathological diagnosis of the biopsy was benign fibrous histiocytoma, subsequent histopathological evaluation of the surgical specimen was malignant fibrous histiocytoma. Thereafter, re-excision of the histiocytoma with a wide margin was performed coupled with reconstruction of the hypopharynx while preserving the larynx. We also report the good long-term survival of this case of low-grade type of malignant fibrous histiocytoma.
    Journal of Nippon Medical School 09/2004; 71(4):301-5. DOI:10.1272/jnms.71.301 · 0.59 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Giant cell rich malignant fibrous histiocytoma accounts for 3 -15% of all malignant fibrous histiocytomas. Currently, the nomenclature giant cell malignant fibrous histiocytoma is reserved for undifferentiated pleomorphic sarcomas with prominent osteoclastic giant cells. It is considered to be synonymous with malignant giant cell tumor of soft parts. We report a case of disseminated giant cell malignant fibrous histiocytoma involving the scalp, cervical node, lungs, spine, abdominal wall, base of penis, gluteal cleft, paraspinal region and back. The diagnosis was established after staining for a panel of immunohistochemical markers namely cytokeratin, vimentin, S100, desmin, CD68 and smooth muscle actin. CD68 positivity in tumor cells helped in arriving at the final diagnosis. It is essential to recognize this tumor as a giant cell rich distinct entity and differentiate from other giant cell rich pleomorphic sarcomas since therapeutic and prognostic differences are being appreciated currently.
    Indian Journal of Pathology and Microbiology 11/2007; 50(4):795-7. · 0.64 Impact Factor

Full-text (2 Sources)

Available from
May 20, 2014