Article

Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli.

Department of Psychology, University of Texas at Austin, Texas 78712, USA.
Journal of Abnormal Psychology (Impact Factor: 4.86). 09/2009; 118(3):670-81. DOI: 10.1037/a0016198
Source: PubMed

ABSTRACT A deletion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has been associated with vulnerability to affective disorders, yet the mechanism by which this gene confers vulnerability remains unclear. Two studies examined associations between the 5-HTTLPR polymorphism and attentional bias for emotional stimuli among nondepressed adults. Biased attention, attention engagement, and difficulty with attention disengagement were assessed with a spatial cuing task using emotional stimuli. Results from Study 1 (N = 38) indicated that short 5-HTTLPR allele carriers experienced greater difficulty disengaging their attention from sad and happy stimuli compared with long allele homozygotes. Study 2 participants (N = 144) were genotyped for the 5-HTTLPR polymorphism, including single nucleotide polymorphism rs25531 in the long allele of the 5-HTTLPR. Consistent with Study 1, individuals homozygous for the low-expressing 5-HTTLPR alleles (i.e., S and LG) experienced greater difficulty disengaging attention from sad, happy, and fear stimuli than high-expressing 5-HTTLPR homozygotes. Because this association exists in healthy adults, it may represent a susceptibility factor for affective disorders that becomes problematic during stressful life experiences.

0 Followers
 · 
126 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Gene–environment studies on adolescents’ peer contexts are important for understanding the interplay between biological and social antecedents of adolescent psychopathology. To this end, this study examined the roles of serotonin transporter (5-HTTLPR) and preadolescent and early adolescent peer rejection and acceptance, as well as the interaction between genotype and environment as predictors of antisocial behavior. Longitudinal data from TRAILS (TRacking Adolescents’ Individual Lives Survey), a Dutch cohort study into adolescent development that includes peer reports of rejection and acceptance assessed at 11.1 and 13.6 years and self-reported antisocial behavior at 19.1 years was used. The interaction between 5-HTTLPR and preadolescent peer rejection predicted antisocial behavior with carriers of the 5-HTTLPR short–short variant most strongly affected. No main or interaction effects were found for early adolescent rejection or interactions involving peer acceptance. Our results extend the gene–environment interaction literature by focusing on peer relationship experiences.
    Merrill-Palmer Quarterly 01/2014; 60(2):193-216. · 1.26 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Stress sensitivity may be one process that can explain why some genetically at-risk individuals are more susceptible to some types of stress-reactive psychopathologies. Dysregulation of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis, including cortisol reactivity to challenge, represents a key aspect of stress sensitivity. However, the degree of stability over time among youth, especially differential stability as a function of particular genetic variants, has not been investigated. A general community sample of children and adolescents (mean age = 11.4; 56% girls) provided a DNA sample and completed 2 separate laboratory stress challenges, across an 18-month follow-up (N = 224 at Time 1; N = 194 at Time 2), with repeated measures of salivary cortisol. Results showed that test-retest stability for several indices of cortisol reactivity across the laboratory challenge visits were significant and of moderate magnitude for the whole sample. Moreover, gene variants of several biologically plausible systems relevant for stress sensitivity (especially 5-HTTLPR and CRHR1) demonstrated differential stability of cortisol reactivity over 18-months, such that carriers of genotypes conferring enhanced environmental susceptibility exhibited greater stability of cortisol levels over time for some LHPA axis indices. Findings suggest that LHPA axis dysregulation may exhibit some trait-like aspects underlying stress sensitivity in youth, especially for those who carry genes related to greater genetic susceptibility to environmental stress. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
    Journal of Abnormal Psychology 02/2015; 124(1):54-67. DOI:10.1037/abn0000030 · 4.86 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The present research investigated an association between the serotonin transporter polymorphism (5-HTTLPR) and sensitivity to the disappearance of facial expressions cross-culturally and found, for the first time, that cultural norms and practices modulate the association. Participants watched both happy-to-neutral and sad-to-neutral movies and judged the point at which the emotional expressions disappeared. As predicted, the results showed that Japanese with the s/s genotype detected the disappearance of facial expressions (particularly the disappearance of smiles) with greater perceptual efficiency than did those with s/l and l/l genotypes, whereas such a tendency was not found in Americans. This suggests that people with the s/s genotype of 5-HTTLPR are more sensitive to environmental changes, but only when the change is culturally important, compared to people with the long allele. Moreover, Asian Americans’ pattern was much more similar to European Americans than to Japanese, supporting the idea that the differences between cultural groups are indeed due to different cultural experiences.
    06/2014; 2(1):72-88. DOI:10.1007/s40167-014-0014-8

Full-text (2 Sources)

Download
77 Downloads
Available from
May 30, 2014