Article

Total Synthesis of Hirsutellone B

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Angewandte Chemie International Edition (Impact Factor: 11.26). 09/2009; 48(37):6870-4. DOI: 10.1002/anie.200903382
Source: PubMed

ABSTRACT Cascading reactions, including the conversion of a TMSepoxy tetraene 1 into the hirsutellone tricyclic core 2, feature heavily in the first total synthesis of the antituberculosis fungal metabolite hirsutellone B. TMS=trimethylsilyl, LA=Lewis acid.

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Jenia Podolsky