Transcatheter Atrial Septal Defect Closure with the AMPLATZER((R)) Atrial Septal Occluder in 13 Dogs: Short- and Mid-Term Outcome
ABSTRACT Transcatheter atrial septal defect (ASD) closure in the dog was first reported in 2005.
Describe the technique and both short- and mid-term outcome of transcatheter ASD closure with the Amplatzer atrial septal occluder (ASO).
Thirteen client-owned dogs with ASD.
Records of the initial 13 dogs in which transcatheter ASD closure was attempted at Texas A&M University were reviewed.
All dogs had hemodynamically relevant septum secundum ASD. Two dogs had concurrent congenital abnormalities. ASOs were deployed in 13 dogs and released in 12. Eleven were released by a right jugular approach and 1 by a transatrial approach through a right lateral thoracotomy. Transthoracic echocardiographic estimates of ASD size were 14.0 + or - 5.4 mm (mean + or - 1 standard deviation) with a range of 7-22 mm. Accidental right atrial release occurred in 1 dog and embolization after release occurred in 2 dogs. Transcatheter ASD closure was successful in 10 dogs. Transthoracic color Doppler echocardiography the day after ASD closure indicated complete occlusion in 5 dogs, trivial to mild residual shunting in 4 dogs, and moderate residual shunting in 1 dog. Follow-up echocardiograms (mean of 12.4 + or - 7.4 months postprocedure) were available for 9 dogs. There was no residual ASD shunting in 6 dogs. In 3 of the 5 dogs with postoperative residual shunting it was judged to be decreased and hemodynamically unimportant relative to the dogs' postoperative evaluations. The mean length of event-free survival in the 10 dogs that underwent successful transcatheter ASD closure was 22.2 + or - 10.2 months.
Conference Paper: A novel magnetic tweezers for manipulation of a single DNA molecule[Show abstract] [Hide abstract]
ABSTRACT: We report a novel magnetic tweezers for manipulation of a single DNA molecule. The micromachined DNA manipulator can stretch and rotate a single DNA molecule using arrayed microcoils. Key platform technologies including localized DNA immobilization, microcoil fabrication and microfluidics, have been integrated to form the magnetic DNA tweezers. A single DNA molecule is specifically attached onto a magnetic bead and a gold surface and manipulated under a magnetic field generated by built-in hexagonally-aligned microcoils. A highly effective method for the construction of DNA two sticky ends is developed, which is compatible with MEMS technologies. We have successfully demonstrated the rotation of the tethered-bead DNA molecule linked to the gold pattern by circular permutation of the currents applied to the microcoils.Micro Electro Mechanical Systems, 2004. 17th IEEE International Conference on. (MEMS); 02/2004
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ABSTRACT: A 3-year-old sexually intact male Standard Poodle was admitted to the veterinary teaching hospital for transcatheter closure of a large atrial septal defect (ASD). The dog had exercise intolerance and was thin. Findings on physical examination were within normal limits with the exception of a left base systolic heart murmur (grade 5/6). The dog was not receiving any medications. Echocardiography and thoracic radiography confirmed the diagnosis of ASD and revealed compensatory changes consistent with a large left to right shunting ASD. Results of serum biochemical analysis and CBC were within reference range limits. Transcatheter ASD closure with an atrial septal occluder (ASO) was performed and failed. An open heart surgical approach under cardiopulmonary bypass was declined by the dog's owners. The dog underwent a novel hybrid approach involving active device fixation under temporary inflow occlusion after transatrial device deployment. The dog recovered with some manageable postoperative complications. As of the last follow-up examination, the dog had 10 months of event-free survival. Transcatheter closure by use of an ASO and open heart patch repair with cardiopulmonary bypass to surgically treat dogs with ASD has been reported. Transcatheter closure is not possible in dogs with large ASD. The novel hybrid procedure reported herein represented a viable alternative to euthanasia.Journal of the American Veterinary Medical Association 02/2010; 236(4):434-9. DOI:10.2460/javma.236.4.434 · 1.67 Impact Factor
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ABSTRACT: The feasibility of surgical correction for almost all canine congenital or acquired cardiac diseases has been demonstrated. Current surgical success rates are remarkably high considering the infrequency with which such procedures are performed. Such results are a testament to the dedication and skill of the various cardiac surgical teams offering these procedures worldwide. However, experience from the medical field indicates that the only way to increase success rates above those presently achieved will be to dramatically increase the frequency with which cardiac surgical teams perform these procedures. Fortunately, lack of case load does not appear to be the limiting factor to such efforts. Rather, lacks of infrastructure and manpower are the major obstacles for expansion of cardiac surgical programs.Veterinary Clinics of North America Small Animal Practice 07/2010; 40(4):605-22. DOI:10.1016/j.cvsm.2010.04.001 · 1.04 Impact Factor