Extracorporeal shock wave therapy: A potential adjuvant treatment for peri-implantitis
ABSTRACT Dental implants have been widely used clinically in recent decades, but peri-implantitis is still a common complication of dental implants with high incidence, which is greatly harmful to the longevity of the dental implant. The current treatment of peri-implantitis is limited and it is hard to achieve optimal re-osseointegration. A new therapy with multi-bioactivities is hoped to solve this problem. There are abundant evidences showing that extracorporeal shock wave therapy has favorable effects on treating delayed union and nonunion of fracture, promoting fracture healing, and inducing bone regeneration. Studies indicated that extracorporeal shock waves may activate osteoblasts and their precursors, and has a bactericidal effect on several oral pathogens. The hypothesis we proposed herein is that extracorporeal shock wave therapy may be an adjuvant treatment for peri-implantitis by controlling infection, inducing alveolar bone regeneration and promoting re-osseointegration.
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ABSTRACT: A physical model is presented to simulate the average step length distribution during nanoparticle tracking analysis experiments as a function of the particle size distribution and the distribution of the number of steps within the tracks. Considering only tracks of at least five steps, numerical simulation could be replaced by a normal distribution approximation. Based on this model, simulation of a step length distribution allows obtaining a much more reliable estimation of the particle size distribution, thereby reducing the artificial broadening of the distribution, as is typically observed by direct conversion of step length to particle size data. As this fitting procedure also allowed including data from particles that were followed for a relatively low number of steps, the measurement time could be reduced for particles that are known to be monodisperse. Whereas the inversion is less sensitive towards the particle size distribution width, still similar values were obtained for both the average diameter and standard deviation of a polystyrene latex sample irrespective of the track length, provided that the latter included at least five steps.Journal of Colloid and Interface Science 09/2010; 352(2):593-600. DOI:10.1016/j.jcis.2010.09.006 · 3.55 Impact Factor
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ABSTRACT: The German doctor Hermann Kümmell described Kümmell's disease as the clinical scenario in which patients suffer a trivial spinal trauma, but develop a symptomatic, progressive, angular kyphosis after a symptom-free period of months to years. Since an intravertebral vacuum phenomenon, which is considered indicative of ischemic osteonecrosis, is often seen in the radiographs of patients with Kümmell's disease, most authors regard ischemic necrosis of the vertebral body as the primary pathogenesis of Kümmell's disease. However, we argue that Kümmell's disease is not commonly associated with typical avascular osteonecrosis of the femoral head and the intravertebral vacuum phenomenon is also present in other diseases. We postulated that even if ischemia plays a role in the pathogenesis of Kümmell's disease, it would not be the proximal cause of Kümmell's disease. In this article, we review the role of fluid shear stress in bone remolding and propose a microcosmic hypothesis in which microcracks lead to decreased fluid shear stress, which acts as the primary cause of Kümmell's disease. This was supported by conclusions drawn from a literature review: (1) fluid shear stress plays a crucial role in bone remodeling, and the osteocyte network is the main sensor of this mechanical stimulus; (2) decreased fluid shear stress will cause disequilibration of bone homeostasis, increasing bone resorption and reducing bone formation; and (3) the fluid flow of lacunar-canalicular porosity (PLC) and fluid shear stress near the microcracks decreases.Medical Hypotheses 08/2011; 77(5):897-9. DOI:10.1016/j.mehy.2011.08.005 · 1.07 Impact Factor
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ABSTRACT: The quest for exploring new frontiers in the field of medical science for efficient and improved treatment modalities has always been on a rise. Extracorporeal shock wave therapy (ESWT) has been enormously used in medical practice, principally, for the management of urolithiasis, cholelithiasis and also in various orthopedic and musculoskeletal disorders. The efficacy of ESWT in the stimulation of osteoblasts, fibroblasts, induction of neovascularization and increased expression of bone morphogenic proteins has been well documented in the literature. However, dentistry is no exception to this trend. The present article enlightens the various applications of ESWT in the field of dentistry and explores its prospective applications in the field of periodontics, and the possibility of incorporating the beneficial properties of shock waves in improving the treatment outcome.Journal of Indian Society of Periodontology 05/2014; 18(3):412-5. DOI:10.4103/0972-124X.134597