Article

Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients.

Flow Cytometry Unit, Immunology Laboratory, Hôpital E. Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, 69437, Lyon cedex 03, France.
European Journal of Intensive Care Medicine (impact factor: 5.17). 09/2009; 35(11):1859-67. DOI:10.1007/s00134-009-1610-5 pp.1859-67
Source: PubMed

ABSTRACT Improvements in survival after septic shock will most likely rely on our capacity to manage individualized therapies based on the measurement of rapidly accessible biomarkers. As the early phase of septic shock is dominated by severe alterations of the cardiovascular system, the predictive value for mortality of pro-vasopressin (pro-AVP) and pro-adrenomedullin (pro-ADM), two vasoactive pro-hormones, was assessed.
In 99 consecutive patients, pro-hormone concentrations were measured (immunoluminometric assay) three times within the first week after the onset of septic shock.
Pro-AVP and pro-ADM concentrations were significantly increased in non-survivors in comparison with survivors and were significantly associated with mortality after both univariate and multivariate analysis. Importantly, when assessed as a pair, pro-ADM and pro-AVP were even more informative.
Both Pro-ADM and pro-AVP appear to be good biomarkers for the prediction of 28-day mortality after septic shock. However, their association in a single variable tends to improve their predictive capacity.

0 0
 · 
1 Bookmark
 · 
36 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

99 consecutive patients
 
accessible biomarkers
 
first week
 
good biomarkers
 
immunoluminometric assay
 
Improvements
 
individualized therapies
 
multivariate analysis
 
predictive capacity
 
predictive value
 
Pro-ADM
 
pro-ADM concentrations
 
pro-adrenomedullin
 
pro-AVP
 
pro-vasopressin
 
septic shock
 
severe alterations
 
single variable