Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia.

Centre for Population Health Sciences, Public Health Sciences Section, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK.
Psychosomatic Medicine (Impact Factor: 4.09). 08/2009; 71(8):901-6. DOI: 10.1097/PSY.0b013e3181b1e538
Source: PubMed

ABSTRACT To determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people.
Subjects consisted of 2312 men and women aged 50 to 80 years participating in the Aspirin for Asymptomatic Atherosclerosis Trial, all of whom were free of symptomatic cardiovascular disease at baseline. Biomarker levels and cognitive ability were measured at baseline with cognition assessed in all subjects using the Mill Hill Vocabulary Scale and in a subgroup of 504 persons using tests of memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. After 5 years, the five-test battery was administered to all participants and scores were used to derive a general cognitive ability factor.
Baseline CRP and fibrinogen levels were associated negatively with age and sex-adjusted follow-up scores on the majority of the cognitive tests, and the general cognitive ability factor (correlations = -0.054 to 0.105, p < .05). In analyses adjusting for baseline cognitive scores, asymptomatic atherosclerotic disease, and cardiovascular risk factors, both markers predicted decline in several cognitive domains (excluding memory). Baseline plasma viscosity, but not hematocrit, was associated negatively with follow-up test scores for general cognitive ability, information processing speed, and mental flexibility (correlations = -0.050 to -0.098, p < .05) and with decline across the same domains (p < .05).
Increased circulating levels of CRP, fibrinogen, and elevated plasma viscosity predicted poorer subsequent cognitive ability and were associated with age-related cognitive decline in several domains, including general ability.

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to identify risk factors for vascular cognitive impairment (VCI) in cerebral infarction patients. Associations between VCI and age, gender, blood pressure, lipid levels, glycosylated hemoglobin, atrial fibrillation, tobacco smoking, alcohol consumption, homocysteine (Hcy), and High-Sensitivity C-Reactive Protein (HS-CRP) were evaluated in patients with cerebral infarction (n = 300) using single factor analysis and multivariate logistic regression analysis. By single factor analysis, the age, glycosylated hemoglobin, atrial fibrillation, blood pressure, Hcy, HS-CRP, tobacco smoking, and alcohol consumption were significantly associated with VCI in these patients. By multivariate logistic regression analysis, the age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP were revealed as independent risk factors. The age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP can serve as predictive factors for VCI in patients with cerebral infarction.
    Cell Biochemistry and Biophysics 09/2014; 71(2). DOI:10.1007/s12013-014-0246-4 · 2.38 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objectives To examine associations between specific inflammatory biomarkers and cognitive function in African Americans (AAs) and European Americans (EAs) with prevalent vascular risk factors.DesignCross-sectional analysis using generalized estimating equations to account for familial clustering; standardized β-coefficients, adjusted for age, sex, and education are reported.SettingCommunity cohort study in Jackson, Mississippi, and Rochester, Minnesota.ParticipantsGenetic Epidemiology Network of Arteriopathy (GENOA)–Genetics of Microangiopathic Brain Injury (GMBI) Study participants.MeasurementsAssociations between inflammation (high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, soluble tumor necrosis factor (TNF) receptor 1 and 2 (sTNFR1, sTNFR2)) and cognitive function (global, processing speed, language, memory, and executive function) were examined in AAs and EAs (N = 1,965; aged 26–95, 64% women, 52% AA, 75% with hypertension).ResultsIn AAs, higher sTNFR2 was associated with poorer cognition in all domains (global: −0.11, P = .009; processing speed: −0.11, P < .001; language: −0.08, P = .002; memory: −0.09, P = .008; executive function: −0.07, P = .03); sTNFR1 was associated with slower processing speed (−0.08, P < .001) and poorer executive function (−0.08, P = .008); higher CRP was associated with slower processing speed (−0.04, P = .024), and higher IL6 was associated with poorer executive function (−0.07, P = .02). In EA, only higher sTNFR1 was associated with slower processing speed (−0.05, P = .007). Associations were not found between cognition and sTNFR2, CRP, or IL6 in EA.Conclusion In a population with high vascular risk, adverse associations between inflammation and cognitive function were especially apparent in AAs, primarily involving markers of TNFα activity.
    Journal of the American Geriatrics Society 12/2014; 62(12). DOI:10.1111/jgs.13165 · 4.22 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Probiotics are consumed in a wide variety of fermented foods to improve health. This study was conducted to investigate the effects of Lactobacillus helveticus-fermented milk (LHFM), on cognitive function in healthy older adults. A 12-week, double-blind, randomized controlled experiment was conducted. Cognitive tests (neuropsychological and cognitive fatigue) and measurements of the perceived stress scale (PSS), geriatric depression scale-short form (GDS-SF), brain-derived neurotrophic factor (BDNF) and whole blood viscosity (WBV) were conducted before and after the experiment. The administration of LHFM for 12 weeks in healthy older adults produced improvement on cognitive tests compared to the placebo group. However, no significant effects were observed for PSS, GDS-SF, BDNF, and WBV. Thus, consumption of LHFM might be beneficial for improving cognitive function.
    Journal of Functional Foods 09/2014; 10:465–474. DOI:10.1016/j.jff.2014.07.007 · 4.48 Impact Factor


1 Download
Available from