Basal Cell Carcinoma of the Nipple-Areola Complex

Department of Otolaryngology-Head and Neck Surgery, Charing Cross Hospital, London, United Kingdom.
Dermatologic Surgery (Impact Factor: 2.11). 08/2009; 35(11):1771-5. DOI: 10.1111/j.1524-4725.2009.01290.x
Source: PubMed


Basal cell carcinoma (BCC) of the nipple-areola complex is uncommon. It has been suggested that BCCs in this region behave more aggressively, with a higher potential for distant spread, than in other anatomical sites.
To address questions about etiology, behavior, optimal treatment, and prognosis of this entity.
A literature search identifying all cases of BCC of the nipple and nipple-areola complex in the English literature from 1893 to 2008.
Thirty-four cases of BCC of the nipple, areola, or both were identified, mostly affecting middle-aged men. The majority of patients were treated with tissue-sparing surgery. There was a metastatic rate of 9.1%, and one patient died from the disease (3.0%).
The optimal treatment of this condition should be local excision, but patients with this condition should be followed up for primary site recurrence and axillary metastasis, because there is greater incidence than with BCC at other anatomical sites. Furthermore, proven axillary metastasis should be surgically treated.

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    • "BCC of the NAC is an uncommon human skin cancer2. After reviewing published literature from 1893 to 2008 (115 years), these authors identified only 33 cases of BCC of the NAC. "
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    ABSTRACT: Basal cell carcinoma (BCC), which frequently occurs in sun-exposed areas of the head and neck region, is the most common cutaneous malignancy. The nipple-areola complex (NAC) is an uncommon site for BCC to develop. BCCs in this region display more aggressive behavior and a greater potential to spread than when found in other anatomical sites. This paper outlines the case of 67-year-old female with a solitary asymptomatic black plaque on the right areola. The lesion was initially recognized as Paget's disease of the nipple by a general surgeon. However, the histopathological features showed a tumor mass of basaloid cells, a peripheral palisading arrangement and scattered pigment granules. Finally, the patient was diagnosed with pigmented BCC of the NAC and was referred to the department of dermatology. Positron emission tomography-computed tomography revealed the absence of distant metastasis. A wide excision was done. The lesion resolved without recurrence or metastasis during 14 months of follow-up.
    Annals of Dermatology 10/2011; 23(Suppl 2):S201-4. DOI:10.5021/ad.2011.23.S2.S201 · 1.39 Impact Factor
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    • "The higher potential of metastasis for tumors in this location is possibly due to the rich network of lymphatic capillaries in the subareolar plexus that provides an easy route for tumor spread [2] [12]. Therefore the treatment of BCCs located at the NAC requires special attention. "
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    ABSTRACT: Basal cell carcinoma (BCC) is the most common malignancy of the skin. It is most frequently seen on the sun-exposed areas of the head and neck region. Occurrence of BCC on the nipple is extremely rare, though the number of the reported cases has been increasing steadily. It has metastatic potential to regional lymph nodes; therefore a more aggressive course can be expected when compared to BCCs located at other sites. Hence, early diagnosis and treatment of BCCs located on this region is of importance. There are 39 reported cases of BCC of nipple-areola complex (NAC) in the English literature. We present an additional case of BCC located on the nipple, presenting with enlargement of the nipple as a sole clinical finding in a 60-year-old man.
    01/2011; 2011:818291. DOI:10.1155/2011/818291
    • "Very few cases of BCC on the pudendum have been reported in the literature.[9–13] Literatures cite posterior neck,[14] scrotum,[15] palm,[16] nipple,[17] areola,[18] shotgun scar,[19] buttock, perineum, axilla, genital region,[20] conjunctiva[21] and Submandibular gland[22] as unusual or rare site of BCC. We are reporting another rare site as anterior chest wall (sternal region). "
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    ABSTRACT: Basal cell carcinoma (BCC) is the most common malignancy of the skin, accounting for approximately 70-80% of all cutaneous cancers. The commonest site of basal cell carcinoma is the face; 80% arise above a line from the corner of the mouth to the ear lobe. The lifetime ultraviolet radiation damage is the most important factor in its pathogenesis, and the vast majority is observed on sun-exposed skin. BCCs can develop in sun-protected areas, but its occurrence is rare. Here we are reporting a case of rare site of BCC with review of literature in a 65-year-old male who presented with a lesion over anterior chest wall. A clinical diagnosis of BCC was made and patient was subjected to excision biopsy. Biopsy revealed it to be a BCC and it was treated with a Dufourmentel flap.
    Journal of Cutaneous and Aesthetic Surgery 05/2010; 3(2):115-8. DOI:10.4103/0974-2077.69026
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