Hereditary Pancreatitis Model WBN/Kob Rat Strain Has a Unique Haplotype in the Pdwk1 Region on Chromosome 7

Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Experimental Animals (Impact Factor: 0.97). 08/2009; 58(4):409-13. DOI: 10.1538/expanim.58.409
Source: PubMed


The WBN/Kob rat strain is a hereditary animal model of chronic pancreatitis and diabetes mellitus. The major WBN/Kob loci for pancreatitis (Pdwk1 and Pdwk2) are located on chromosomes 7 and X, respectively. In this study, polymorphisms were sought for candidate genes in the Pdwk1 and Pdwk2 regions. Nucleotide polymorphisms were found in 14 candidate genes examined in the Pdwk1 region. These polymorphisms were not associated with functional changes, and hence were unlikely to be a cause of pancreatitis. Seven nucleotide polymorphisms in three candidate genes, Rac2, Grap2, and Xpnpep3, located within a 3.3-Mb region were not found in 14 other inbred rat strains. These results suggest that WBN/Kob has a unique haplotype block in the chromosomal region contatining Pdwk1.

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Available from: Masayuki Mori, Apr 01, 2015
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    • "Mitochondrial swelling after ischemia and stasis of pancreatic juice were further reported to be responsible for early pancreatic changes [125,126]. Chromosomal mapping of WBN/Kob rats showed a unique haplotype block in the chromosomal region Pdwk1 (pancreatitis and diabetes mellitus in WBN/Kob locus 1) on chromosome 7 after identification of nucleotide polymorphisms of three candidate genes that were not found in other inbred rat strains [127]. These genes (Rac2, Grap2 and Xpnpep3) exert different functions. "
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