Pseudoangiomatous stromal hyperplasia of the breast

Histopathology Department, Dubai Hospital, PO Box 7272, Dubai, United Arab Emirates.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 09/2009; 133(8):1335-8. DOI: 10.1043/1543-2165-133.8.1335
Source: PubMed


Pseudoangiomatous stromal hyperplasia is a relatively common lesion of the breast. In general, it is less commonly found as a clinically palpable mass and is more commonly found as incidental microscopic foci. It is a benign proliferative, probably neoplastic, hormonally driven process of the mammary stromal myofibroblasts. The clinical, radiologic, and cytologic findings can resemble those of fibroadenoma. Histologically, it can be confused with low-grade angiosarcoma. The exact etiology of pseudoangiomatous stromal hyperplasia is still controversial, but a neoplastic process of the stromal myofibroblasts, with a hormonal stimulus in its development and progression, is the favored theory. Most lesions can be cured by complete surgical excision, and patients undergoing the excision have a good prognosis.

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