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Diketopiperazine alkaloids from a deep ocean sediment derived fungus Penicillium sp.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, P.R. China.
CHEMICAL & PHARMACEUTICAL BULLETIN (Impact Factor: 1.56). 09/2009; 57(8):873-6. DOI: 10.1248/cpb.57.873
Source: PubMed

ABSTRACT Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.

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