Article

Antitumor activity and DNA-binding investigations of the Zn(II) and Cu(II) complexes with isoeuxanthone.

College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
CHEMICAL & PHARMACEUTICAL BULLETIN (impact factor: 1.59). 09/2009; 57(8):814-8. pp.814-8
Source: PubMed

ABSTRACT Two new complexes ZnL(2) (1) and CuL(2) (2) (here, HL=isoeuxanthone) have been synthesized and characterized by elemental analyses, molar conductance, infrared spectra (IR), (1)H-NMR and UV-Vis measurements. The interactions of them with calf thymus DNA (ct DNA) have been investigated by absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Experimental results revealed an intercalative interaction with DNA for the complexes; furthermore the binding affinity of 2 is higher than that of 1 according to the calculated binding constant values. In addition, they were evaluated for their cytotoxic activities toward human esophageal cancer (ECA109) and human gastric cancer (SGC7901) cells by MTT assay. Both of them showed significant cytotoxic potency.

0 0
 · 
1 Bookmark
 · 
81 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

binding affinity
 
calculated binding constant values
 
calf thymus DNA
 
circular dichroism spectroscopy
 
ct DNA
 
cytotoxic activities
 
elemental analyses
 
Experimental results
 
fluorescence spectroscopy
 
human esophageal cancer
 
human gastric cancer
 
IR
 
molar conductance
 
MTT assay
 

Huifang Wang