A case study of Neuro-psycho-Behcet's Syndrome presenting with psychotic attack
ABSTRACT Behçet's disease is a multisystem inflammatory disorder that presents with a classic triad of recurrent oral and genital ulcerations and uveitis with hypopyon. The initial symptom of Behçet's disease is neurological in only 3% of cases. Although Neuro-Behçet's Syndrome commonly presents with focal neurological symptoms, it is possible that psychiatric symptoms could be the first manifestation of the disease. To our knowledge, this is the first case report of Neuro-Behçet's Syndrome that presents with an acute psychotic attack.
- SourceAvailable from: Domenico De Berardis
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- "However, we cannot exclude that, in this patient, onset of symptoms may be triggered by an involvement of CNS, as MRI findings across time may be reflective of BD CNS activity, and treatment resistance caused by prolonged corticosteroid therapy even if actual brain MRI was negative and corticosteroids were discontinued in 2002. It has been reported that involvement of CNS may cause a neurobehavioral psychotic syndrome that can consist of visual and auditory hallucinations, persecutory delusions, disorganized behavior and speech, mania or hypomania, loss of insight, disinhibition, psychomotor agitation or retardation, and social withdrawal (Table 1)  . Azathioprine is effective in the treatment of BD , but may cause several serious hematological side effects such as leukopenia and pancytopenia . "
ABSTRACT: Behçet's disease (BD) is a recurrent inflammatory disorder involving multisystems of the body. Neuropsychiatric symptoms, like psychosis and depression, often occur in BD, but the safety and efficacy of combined clozapine-azathioprine treatment have never been assessed. We here report on a 37-year-old man with BD and treatment-resistant schizophrenia who obtained an improvement following the introduction of clozapine in addition to azathioprine, without developing agranulocytosis or other severe adverse side effects during a 2-year follow-up.General hospital psychiatry 07/2012; 35(2). DOI:10.1016/j.genhosppsych.2012.06.007 · 2.61 Impact Factor
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ABSTRACT: Behcet's disease (BD) is a multi-systemic inflammatory disease of unknown origin that affects nearly all organs. Recent reports of BD with myelodysplastic syndrome (MDS) often note an association with gastrointestinal involvement and trisomy 8. We herein report on a case of a 51-year-old man who had refractory schizophrenia and developed gastrointestinal BD and MDS with trisomy 8 and 9. He visited our hospital due to fever and abdominal pain. Multiple ulcerations in the colorectum were observed on colonoscopy, and he was diagnosed with intestinal BD. During the treatment of intestinal BD, anemia and thrombocytopenia developed. His bone marrow study revealed myelodysplastic syndrome (refractory anemia with ringed sideroblast) with trisomy 8 and trisomy 9. We report a rare case of intestinal BD accompanied by schizophrenia and myelodysplastic syndrome with trisomy 8 and 9.01/2013; 20(6):369. DOI:10.4078/jrd.2013.20.6.369
- Neurological Sciences 01/2013; 34(10). DOI:10.1007/s10072-013-1304-1 · 1.45 Impact Factor