Article

Recent progress in the biology and physiology of sirtuins

Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Nature (Impact Factor: 42.35). 08/2009; 460(7255):587-91. DOI: 10.1038/nature08197
Source: PubMed

ABSTRACT The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

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Available from: Raul Mostoslavsky, Apr 19, 2014
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    • "Interest in sirtuins grew when Sir2 was shown to slow aging in yeast mother cells (Kaeberlein et al. 1999). Many subsequent studies showed similar effects on aging, supporting the ideas of sirtuins like longevitypromoting effectors in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and mice (Bauer et al. 2009; Berdichevsky et al. 2006; Finkel et al. 2009; Rizki et al. 2010; Rogina and Helfand 2004; Viswanathan and Guarente 2011; Viswanathan et al. 2005). Banerjee et al. (2012) demonstrated how in D. Melanogaster, overexpression of Sir2 extended the lifespan, whereas deletion of Sir2 reduces significantly the lifespan. "
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    ABSTRACT: The sirtuins comprise a highly conserved family proteins present in virtually all species from bacteria to mammals. Sirtuins are members of the highly conserved class III histone deacetylases, and seven sirtuin genes (sirtuins 1-7) have been identified and characterized in mammals. Sirtuin activity is linked to metabolic control, apoptosis, cell survival, development, inflammation, and healthy aging. In this review, we summarize and discuss the potential mutual relations between each sirtuin and cardiovascular health and the impact of sirtuins on oxidative stress and so age-related cardiovascular disorders, underlining the possibility that sirtuins will be novel targets to contrast cardiovascular risks induced by aging.
    Age 08/2015; 37(4):9804. DOI:10.1007/s11357-015-9804-y · 3.45 Impact Factor
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    • "To elucidate the role of metabolism-sensitive molecules in adult neurogenesis, we focused on SIRT1, which is a nicotinamide adenine dinucleotide (NAD) + -dependent histone deacetylase (Finkel et al., 2009; Haigis and Guarente, 2006; Haigis and Sinclair, 2010). The requirement of NAD + for deacetylation makes SIRT1 an ideal mediator of the cross-talk between metabolism and epigenetic regulation. "
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    Development 12/2014; 141(24):4697-4709. DOI:10.1242/dev.117937 · 6.27 Impact Factor
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    • "Por otro lado, las HDAC se pueden agrupar en dos familias (Gallinari y col, 2007): las HDAC clásicas, dependientes de zinc como cofactor, y que incluyen a las clases I, II y IV y las Sirtuinas o Clase III, dependientes del cofactor NAD (Sauve y Youn, 2012; Finkel y col, 2009). De nuevo una molécula central en la regulación del metabolismo como es el NAD aparece como clave para la regulación de las HDACs. "
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    Sociedad Española de Ciencias Fisiológicas (ISSN: 1889-397X), Spain; 12/2014
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