A generic bioheat transfer thermal model for a perfused tissue.

Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
Journal of Biomechanical Engineering (Impact Factor: 1.52). 08/2009; 131(7):074506. DOI: 10.1115/1.3127260
Source: PubMed

ABSTRACT A thermal model was needed to predict temperatures in a perfused tissue, which satisfied the following three criteria. One, the model satisfied conservation of energy. Two, the heat transfer rate from blood vessels to tissue was modeled without following a vessel path. Three, the model applied to any unheated and heated tissue. To meet these criteria, a generic bioheat transfer model (BHTM) was derived here by conserving thermal energy in a heated vascularized finite tissue and by making a few simplifying assumptions. Two linear coupled differential equations were obtained with the following two variables: tissue volume averaged temperature and blood volume averaged temperature. The generic model was compared with the widely employed empirical Pennes' BHTM. The comparison showed that the Pennes' perfusion term wC(p)(1-epsilon) should be interpreted as a local vasculature dependent heat transfer coefficient term. Suggestions are presented for further adaptations of the general BHTM for specific tissues using imaging techniques and numerical simulations.

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