Article

Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders.

Department of Psychology, City University of New York, City College of New York, New York, NY 10030, USA.
Journal of Consulting and Clinical Psychology (impact factor: 4.85). 09/2009; 77(4):607-19. DOI:10.1037/a0016227 pp.607-19
Source: PubMed

ABSTRACT The authors compared the effectiveness of the Seeking Safety group, cognitive-behavioral treatment for substance use disorder and posttraumatic stress disorder (PTSD), to an active comparison health education group (Women's Health Education [WHE]) within the National Institute on Drug Abuse's Clinical Trials Network. The authors randomized 353 women to receive 12 sessions of Seeking Safety (M = 6.2 sessions) or WHE (M = 6.0 sessions) with follow-up assessment 1 week and 3, 6, and 12 months posttreatment. Primary outcomes were the Clinician Administered PTSD Scale (CAPS), the PTSD Symptom Scale-Self Report (PSS-SR), and a substance use inventory (self-reported abstinence and percentage of days of use over 7 days). Intention-to-treat analysis showed large, clinically significant reductions in CAPS and PSS-SR symptoms (d = 1.94 and 1.12, respectively) but no reliable difference between conditions. Substance use outcomes were not significantly different over time between the two treatments and at follow-up showed no significant change from baseline. Study results do not favor Seeking Safety over WHE as an adjunct to substance use disorder treatment for women with PTSD and reflect considerable opportunity to improve clinical outcomes in community-based treatments for these co-occurring conditions.

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Keywords

12 months posttreatment
 
12 sessions
 
authors randomized 353 women
 
clinical outcomes
 
clinically significant reductions
 
Clinician Administered PTSD Scale
 
considerable opportunity
 
Drug Abuse's Clinical Trials Network
 
follow-up assessment 1 week
 
National Institute
 
posttraumatic stress disorder
 
Primary outcomes
 
reliable difference
 
Seeking Safety
 
Seeking Safety group
 
substance use disorder
 
substance use disorder treatment
 
substance use inventory
 
Substance use outcomes
 
Women's Health Education [WHE]