Non-compliance and non-persistence to medication regimens are significant problems of realizing the optimal management in chronic obstructive pulmonary disease, clears up from the systematic review. Underuse and overuse are both important factors of inadequate therapy. Poor compliance increases the frequency of exacerbations, hospitalizations, and results higher mortality and reduced quality of life. When prescribing the medications, patient characteristics should be considered as well as the expected compliance and persistence. Patient education and better doctor-patient relationship can increase the efficiency of treatments.
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