Exercise improves body fat, lean mass, and bone mass in breast cancer survivors

Yale School of Medicine, New Haven, Connecticut, USA.
Obesity (Impact Factor: 4.39). 09/2009; 17(8):1534-41. DOI: 10.1038/oby.2009.18
Source: PubMed

ABSTRACT Given the negative effects of a breast cancer diagnosis and its treatments on body weight and bone mass, we investigated the effects of a 6-month randomized controlled aerobic exercise intervention vs. usual care on body composition in breast cancer survivors. Secondary aims were to examine the effects stratified by important prognostic and physiologic variables. Seventy-five physically inactive postmenopausal breast cancer survivors were recruited through the Yale-New Haven Hospital Tumor Registry and randomly assigned to an exercise (n = 37) or usual care (n = 38) group. The exercise group participated in 150 min/week of supervised gym- and home-based moderate-intensity aerobic exercise. The usual care group was instructed to maintain their current physical activity level. Body composition was assessed at baseline and 6-months through dual-energy X-ray absorptiometry (DXA) by one radiologist blinded to the intervention group of the participants. On an average, exercisers increased moderate-intensity aerobic exercise by 129 min/week over and above baseline levels compared with 45 min/week among usual care participants (P < 0.001). Exercisers experienced decreases in percent body fat (P = 0.0022) and increases in lean mass (P = 0.047) compared with increases in body fat and decreases in lean mass in usual care participants. Bone mineral density (BMD) was also maintained among exercisers compared with a loss among usual care participants (P = 0.043). In summary, moderate-intensity aerobic exercise, such as brisk walking, produces favorable changes in body composition that may improve breast cancer prognosis.

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Available from: Susan T Mayne, Jul 18, 2014
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    Clinical Nursing Research 10/2014; DOI:10.1177/1054773814553298 · 0.87 Impact Factor
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    • "In addition to the measurement of bone and the diagnosis of osteoporosis, dual-energy X-ray absorptiometry (DXA) has become an established technique for the measurement of body composition in both research and clinical practise. DXA has become a common primary outcome for investigations of the effects of interventions or disease on body composition (Irwin et al., 2009) and the extent of obesity in patients (Uusi-Rasi et al., 2009) In addition, more recent models of DXA are able to quantify android and gynoid fat accumulation, and have been used for investigations of cardiovascular risk (Berends et al., 2009). "
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