Effect of honey on serum cholesterol and lipid values.

Department of Obstetrics and Gynecology, University Hospital Giessen and Marburg, Germany.
Journal of medicinal food (Impact Factor: 1.7). 07/2009; 12(3):624-8. DOI: 10.1089/jmf.2008.0188
Source: PubMed

ABSTRACT Small studies have suggested that honey benefits patients with high cholesterol concentrations. The present study aimed to confirm this finding in a larger group of subjects. Sixty volunteers with high cholesterol, stratified according to gender and hydroxymethylglutaryl-coenzyme A reductase inhibitor (statin) treatment (yes/no), were randomized to receive 75 g of honey solution or a honey-comparable sugar solution once daily over a period of 14 days. Baseline measurements, including body mass index (BMI) and lipid profile, were obtained, and subjects also completed dietary questionnaires and the Inventory for the Assessment of Negative Bodily Affect-Trait form (INKA-h) questionnaire. Measurements were repeated 2 weeks later. BMI and high-density lipoprotein (HDL) cholesterol values were significantly correlated (r = -0.487; P < .001) as were BMI and a lower ratio of low-density lipoprotein (LDL) cholesterol to HDL cholesterol (r = 0.420; P < .001), meaning that subjects with a high BMI had a lower HDL cholesterol value. INKA-h scores and LDL cholesterol values were also significantly correlated (r = 0.273, P = .042). Neither solution influenced significantly cholesterol or triglyceride values in the total group; in women, however, the LDL cholesterol value increased in the sugar solution subgroup but not in the women taking honey. Although ingesting honey did not reduce LDL cholesterol values in general, women may benefit from substituting honey for sugar in their diet. Reducing the BMI lowers the LDL cholesterol value, and psychological interventions also seem important and merit further investigation.

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    • "Lastly, a recent study of male and female subjects who randomly received a 75-g honey solution or a sugar solution similar to honey for 14 days has shown that the male LDL-cholesterol values were not significanly reduced by the honey supplementation; however, in women, these values increased in the group that received the sugar solution but not in that fed honey (Münstedt et al., 2009b). Therefore, female LDL-cholesterol values may be slightly reduced by substituting sugar with honey in the daily diet, evidencing an antihypercholesterolemic effect as a result of honey consumption (Münstedt et al., 2009b). "
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    ABSTRACT: Honey, a natural substance produced by honeybees, is composed of a complex mixture of carbohydrates, water, and a small amount of proteins, vitamins, minerals, and phenolic compounds. Fructose, glucose and maltose are among the various types of sugars present in honey. Used for millennia as both food and medicine, honey has been associated with improved antioxidant capacity, modulation of the immune system, antimicrobial activities, influence on lipid values (through antihypercholesterolemic effects) and regulation of glycemic responses, among other benefits. The aim of this article was to review the effects of natural honey intake on human health, with particular reference to its influence on glycemic regulation. Several studies have focused on the potential use of honey as a nutritional supplement for healthy individuals and for those with impaired glucose tolerance, diabetes, and their related comorbidities. Such investigations have found that, compared to glucose and sucrose, the consumption of honey decreases glycemic levels and blood lipids in healthy, diabetic and hyperlipidemic individuals. Moreover, long periods of honey intake seem to reduce fasting glucose levels in humans, suggesting that honey consumption influences plasma glucose regulation, mainly through a normo- or hypoglycemic effect. Therefore, honey may be proposed as a nutritional dietary supplement for healthy individuals and for those suffering from alterations in glycemic regulation.
    08/2011; 38(2):303-317. DOI:10.4067/S0718-16202011000200015
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    • "that fructose has no immediate effects on the lipid metabolism ( Münstedt et al . , 2009a ) . Such effects require long - term honey consumption ( Münstedt et al . , 2009b ) ."
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    ABSTRACT: Studies suggest that honey has less influence on serum glucose concentrations than monosaccharides and disaccharides. Previous studies, however, have only analysed glucose metabolism. This study investigated the influence of two types of honey (rapeseed and acacia) on the serum levels of glucose, fructose, insulin and C-peptide values in healthy subjects. The results were compared with honey-comparable glucose-fructose solutions. All solutions contained 75 g of glucose and/or fructose. We found significantly higher fructose serum levels with rapeseed honey after 2 h but no such differences for acacia honey. C-peptide levels were significantly higher after administration of both honeys after 1 and 2 h. For the first time it has been found out that honey ingestion leads to a rise of blood fructose concentration: in one case, this rise was lower than that achieved after fructose/glucose controls, in the other cases it was same as after the controls. Fructose metabolism may be inhibited by unidentified substances present in the rapeseed honey. Further study to elucidate underlying mechanisms may be worthwhile, as usually there is no differentiation between the different types of honey.
    European journal of clinical nutrition 01/2011; 65(1):77-80. DOI:10.1038/ejcn.2010.186 · 2.95 Impact Factor
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    • "who also reported that natural honey improved lipid . Also with 8-week consumption of honey beneficial effects on blood lipids of diabetic patients (Bahrami et al., 2009); on LDL cholesterol only in n (Münstedt et al., 2009) and in reducing were studied. "
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    ABSTRACT: The effects of natural honey on body weight and blood lipid profile in both sexes of normal weight and obese adults have been investigated. Body mass index (BMI), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were used as parameters of comparison of normal and obese adults. A non significant reduction in BMI was observed in all ethnic groups in both genders of obese as well as normal weight subjects. Honey intake significantly reduced TC in obese subjects of both genders of Baloch and Punjabi and Hazara females, in contrast to reduction in both genders of Baloch and males of Pathan normal weight control subjects. Triglycerides were lowered in obese subjects of all the ethnic groups of both the sexes except females of Hazara; comparably reduction was noticed in normal weight control males of Baloch and females of Punjabi only. The significant increases in HDL-c in obese of both the genders of Baloch and Pathan and males of Hazars, were observed and in normal weight controls similar response was shown in males of Pathan and Punjabi only. Significant decreases in the level of low density lipoprotein (LDL-c) cholesterol in obese subjects of all ethnic groups except females of Hazara and Punjabi were found compared to none of the significantly affected batch in the normal weight control group. Honey demonstrated prominent reducing effect on TC, LDL-c & TG and HDL cholesterol enhancing ability in the obesity of most of the ethnic groups in both the genders. Comparably lowering of TC, TG and increasing of HDL-c with honey is also observed in normal weight subjects, however, imperceptibly in very few ethnic groups. Thus honey consumption had shown exceedingly improving effect on lipid profile in obesity compared to normal weight status.
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