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Escaping the firing squad: acetylation of BubR1 protects it from degradation in checkpoint cells.

The Gurdon Institute, Cambridge, UK.
The EMBO Journal (Impact Factor: 9.82). 08/2009; 28(14):1991-3. DOI: 10.1038/emboj.2009.149
Source: PubMed
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    ABSTRACT: Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
    Genes & development 12/2009; 23(24):2799-805. · 12.08 Impact Factor

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