Article

[Chemotherapy in advanced rectal cancers].

Service de cancérologie, CHU de Treichville.
Le Mali médical 02/2006; 21(2):1-4. pp.1-4
Source: PubMed

ABSTRACT The aim of this retrospective study was to specify the therapeutic strategy in the management of locally advanced rectal cancers in our practice in front of lack of radiotherapy.
This study had concerned 52 patients suffering from locally advanced rectal cancers, with mean age of 44 years old (range: 22-68). Evaluation for down staging was based on clinical, CT scan and intraoperative features. Patients were classified as T4NXM0. Thirty one patients (57,7%) had left iliac colostomy associated with a neoadjuvant chemotherapy, 12 had a left iliac palliative colostomy and 9 had chemotherapy only.
Thirty two patients (80%) suffered from digestive toxicity due to chemotherapy, 11 patients had hematologic toxicity and 4 other had skin and mucous toxicity. Between the thirty one patients who had colostomy and chemotherapy, 4 (12,9%) responded well and underwent to curative rectal resection, in the remaining patients, the colostomy stayed palliative. The median survey time was 9,5 months.
Our poor results confirmed the need of early detection and radiotherapy in the management of our patients.

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Keywords

11 patients
 
44 years old
 
52 patients
 
clinical
 
CT scan
 
curative rectal resection
 
digestive toxicity
 
iliac colostomy
 
intraoperative features
 
left iliac palliative colostomy
 
median survey time
 
mucous toxicity
 
neoadjuvant chemotherapy
 
patients
 
poor results
 
rectal cancers
 
remaining patients
 
retrospective study
 
therapeutic strategy