Article

Metaanalytic Connectivity Modeling: Delineating the Functional Connectivity of the Human Amygdala

Neuroscience Institute, Scott and White Memorial Hospital, Temple, Texas 76508, USA.
Human Brain Mapping (Impact Factor: 6.92). 11/2009; 31(2):173-84. DOI: 10.1002/hbm.20854
Source: PubMed

ABSTRACT Functional neuroimaging has evolved into an indispensable tool for noninvasively investigating brain function. A recent development of such methodology is the creation of connectivity models for brain regions and related networks, efforts that have been inhibited by notable limitations. We present a new method for ascertaining functional connectivity of specific brain structures using metaanalytic connectivity modeling (MACM), along with validation of our method using a nonhuman primate database. Drawing from decades of neuroimaging research and spanning multiple behavioral domains, the method overcomes many weaknesses of conventional connectivity analyses and provides a simple, automated alternative to developing accurate and robust models of anatomically-defined human functional connectivity. Applying MACM to the amygdala, a small structure of the brain with a complex network of connections, we found high coherence with anatomical studies in nonhuman primates as well as human-based theoretical models of emotive-cognitive integration, providing evidence for this novel method's utility.

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Available from: Angela R Laird, Sep 02, 2015
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    • "Although previous studies have indirectly analyzed in neurological samples the functionality of BA37 using functional MRI (fMRI) and diffusion tensor imaging (DTI) [52] [53] [54] their results have limited generalizability due to the methodologies (e.g., task-specific fMRI which is not generalizable and DTI which is influenced by deeply myelinated regions and fails where fibers cross) being employed [47]. Thus, strong empirical evidence is lacking as to how BA37 is functionally connected to the rest of the brain, despite the importance of this multimodal brain area in visual and cognitive processes. "
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    • "amygdala volumes. The amygdala has extensive reciprocal connections with the anteriobasal subdivision of the insula (Augustine, 1996; Nieuwenhuys, 2012), and shows functional connectivity with the insula (Robinson et al., 2010), including during resting state (Roy et al., 2009; Cauda et al., 2011) and emotional processing (Stein et al., 2007). The amygdala enlargement observed in our study is unlikely to be driven by comorbid depression. "
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