Metaanalytic Connectivity Modeling: Delineating the Functional Connectivity of the Human Amygdala

Neuroscience Institute, Scott and White Memorial Hospital, Temple, Texas 76508, USA.
Human Brain Mapping (Impact Factor: 5.97). 11/2009; 31(2):173-84. DOI: 10.1002/hbm.20854
Source: PubMed


Functional neuroimaging has evolved into an indispensable tool for noninvasively investigating brain function. A recent development of such methodology is the creation of connectivity models for brain regions and related networks, efforts that have been inhibited by notable limitations. We present a new method for ascertaining functional connectivity of specific brain structures using metaanalytic connectivity modeling (MACM), along with validation of our method using a nonhuman primate database. Drawing from decades of neuroimaging research and spanning multiple behavioral domains, the method overcomes many weaknesses of conventional connectivity analyses and provides a simple, automated alternative to developing accurate and robust models of anatomically-defined human functional connectivity. Applying MACM to the amygdala, a small structure of the brain with a complex network of connections, we found high coherence with anatomical studies in nonhuman primates as well as human-based theoretical models of emotive-cognitive integration, providing evidence for this novel method's utility.

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