Article

Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock.

Service d'Anesthésie et de Réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille and Université de la Méditerranée, Marseille, France.
Anesthesiology (impact factor: 5.36). 09/2009; 111(2):366-71. DOI:10.1097/ALN.0b013e3181aae72d pp.366-71
Source: PubMed

ABSTRACT Growing evidence suggests that the microvascular dysfunction is the key element of the pathogenesis of septic shock. This study's purpose was to explore whether the outcome of septic shock patients after early resuscitation using early goal-directed therapy is related to their muscle tissue oxygenation.
Tissue oxygen saturation (Sto2) was monitored in septic shock patients using a tissue spectrometer (InSpectra Model 325; Hutchinson Technology, Hutchinson, MN). For the purpose of this retrospective study, the Sto2 values were collected at the first measurement done after the macrohemodynamic variables (mean arterial pressure, urine output, central venous saturation in oxygen) were optimized.
After the hemodynamic variables were corrected, no difference was observed between the nonsurvivors and survivors, with the exception of pulse oximetry saturation (94% [92-97%] vs. 97% [94-99%], P = 0.04). The Sto2 values were significantly lower in the nonsurvivors than in the survivors (73% [68-82%] vs. 84% [81-90%], P = 0.02). No correlations were found between the Sto2 and Spo2 (P = 0.7).
In septic shock patients, tissue oxygen saturation below 78% is associated with increased mortality at day 28. Further investigations are required to determine whether the correction of an impaired level of tissue oxygen saturation may improve the outcome of these patients.

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    Article: Knee area tissue oxygen saturation is predictive of 14-day mortality in septic shock.
    H Ait-Oufella, J Joffre, P Y Boelle, A Galbois, S Bourcier, J L Baudel, D Margetis, M Alves, G Offenstadt, B Guidet, E Maury
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    Article: Tissue oxygen saturation as a goal, but when and where should we measure it?
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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

central venous saturation
 
first measurement
 
goal-directed therapy
 
Growing evidence
 
hemodynamic variables
 
Hutchinson Technology
 
impaired level
 
InSpectra Model 325
 
key element
 
macrohemodynamic variables
 
muscle tissue oxygenation
 
pulse oximetry saturation
 
retrospective study
 
septic shock
 
septic shock patients
 
Sto2 values
 
study's purpose
 
tissue oxygen saturation
 
tissue spectrometer
 
urine output